Xavier Musketeers vs St. John's Red Storm Prediction, Odds and Picks for Today, 01/22/25

The Xavier Musketeers will travel to New York City on Wednesday night to play a Big East Conference game against the St. John’s Red Storm. St. John’s is ranked #20 in the latest AP Top 25 Poll and has lost just 3 times this season. They are tied for 1st place in the conference standings and will look to continue their quest for a title with a win here. Xavier has won their last 3 games but has not been as good as people expected in the preseason. They were unable to defend home court against St. John’s earlier in the month and we expect a similar result here. The Red Storm won the first matchup 82-72 and we like St. John’s to cover the 7.5-point spread in this one.

St. John’s defense should give Xavier major problems. The Musketeers scored just 72 points and shot 22.2 percent from beyond the arc in their last matchup. According to KenPom, the Red Storm’s defense is ranked #5 in adjusted defensive efficiency and #11 in two-point percentage. Xavier is ranked #200 nationally in two-point percentage, so points in the paint may be hard to come by for them inside Madison Square Garden. St. John’s is 12-0 at home this year and has won 5 straight games, so we like them to comfortably take care of business here.

Xavier vs St. John’s prediction: St. John’s -7.5 (-110) available at time of publishing. Playable to 9.5.

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