Colorado Buffaloes vs West Virginia Mountaineers Prediction, Odds and Picks for Today, 03/12/25

We head to the second round of the Big 12 Tournament in Kansas City with a Colorado Buffaloes vs West Virginia Mountaineers prediction. The Buffs had to win an opening-round game against TCU to get to this spot, and their season will end whenever they lose this week. West Virginia will play its first game of the tournament on Wednesday afternoon, and sometimes that can be a tricky spot. Bracketologist Joe Lunardi and the other experts have West Virginia safely into the field of 68, but I would feel much better about the Mountaineers if they get 1 more victory. I think this is a spot with a lot of pressure on the Mountaineers, and they may find themselves struggling to survive against a loose and carefree Colorado squad. I am going to take the points with the Buffs, with the line currently set at +6.5.

These teams met once in the regular season, a game that West Virginia won 78-70 in Boulder. The Buffaloes have gotten much better since then, for what it is worth, despite finishing last in the conference. They will need to continue their hot shooting if they want to win, but that is hard to do against the WVU defense. In particular, the Mountaineers are a top 10 team when it comes to defending the 3-point arc. Colorado will need to find a way to defy that metric. So why back the Buffs here? First, West Virginia struggles offensively — and tends to win in tight games. Second, WVU prefers a very slow, defensive grind of a game — and those kinds of games often lead us to the win-but-no-cover outcome. I also like that Colorado played already and got comfortable on that gawd-awful gym floor (seriously, what are we doing with the Roman numerals everywhere?!?!), and there is a chance West Virginia starts slow and has to grind this one out. Give me the underdogs with nothing to lose.

Colorado vs West Virginia prediction: Colorado +6.5 (-110) available at time of publishing. Playable at that number.

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