Mount Saint Mary's Mountaineers vs Duke Blue Devils Prediction, Odds and Picks for Today, 03/21/25

The NCAA Tournament’s first round features a matchup between the top-seeded Duke Blue Devils (31-3) and the 16th-seeded Mount St. Mary’s Mountaineers (23-12). Mount St. Mary’s advanced by defeating American University 83-72 in the First Four, showcasing an impressive offensive performance. The team shot 58% from the field, 41% from three-point range, and 82% from the free-throw line. Sophomore guard Dallas Hobbs contributed 17 points, while frontcourt players Jedy Cordilia and Dola Adebayo each added 22 points. Duke enters the tournament on an 11-game winning streak. Freshman standout Cooper Flagg, who recently suffered a left ankle sprain during the ACC Tournament, is expected to return for this game. Head coach Jon Scheyer expressed optimism about Flagg’s availability, stating it’s “full steam ahead” for the tournament opener.

Both teams have been performing exceptionally against the spread (ATS) across various scenarios—whether as underdogs, favorites, after wins, or regardless of rest advantages—making it challenging to identify a clear betting edge. The current betting line favors Duke by 32.5 points. While Duke is anticipated to win, covering such a substantial spread is uncertain. Mount St. Mary’s recent offensive surge and Duke’s potential cautious approach with Flagg’s return could result in a more competitive game than the spread suggests. Therefore, taking Mount St. Mary’s +32.5 appears to be a reasonable prediction.

Mount St. Mary’s vs Duke prediction: MSM +32.5 (-110) available at time of publishing. Playable to 30.

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