McNeese State Cowboys vs Clemson Tigers Prediction, Odds and Picks for Thursday, 03/20/25

The McNeese Cowboys and the Clemson Tigers will meet on Thursday for round one of the NCAA Tournament. This game will be played in Providence, and it will tip off at 3:15pm Eastern Standard Time. Clemson scored a #5 seed on Selection Sunday after finishing the season 27-6 while McNeese won the Southland Conference to get their bid. The spread is currently at 7.5 points, and we see McNeese covering the spread. Our best bet of the game is McNeese +7.5.

We like McNeese to cover the spread in this one because they are one of the best mid major programs in the country. The Cowboys are riding an 11-game win streak and have lost just one game in 2025. They have proven they can play with the best teams in college basketball as they lost to Alabama by just eight points. Their defense should be able to keep up with Clemson’s offense and keep this game close. According to KenPom, McNeese’s defense is ranked #35 in two-point percentage, #39 in effective field goal percentage and #18 in turnover percentage. Take McNeese to cover here.

McNeese vs Clemson prediction: McNeese +7.5 (-110) available at time of publishing. Playable to 6.

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