Gonzaga Bulldogs vs Houston Cougars Prediction, Odds and Picks for Saturday, 03/22/25

The Gonzaga Bulldogs and the Houston Cougars will meet on Saturday in Wichita for round 2 of the NCAA Tournament. This should be one of the most competitive games of the day, as both Houston and Gonzaga are ranked in the top 10 by KenPom. The last meeting between 2 top 10 KenPom teams was in the round of 32 was in 2021, when Loyola Chicago upset #1 seed Illinois. I expect the underdog to put up a great fight in this one again and cover the spread. The spread is currently set at 5.5 points in favor of the Cougars and my best Gonzaga vs Houston is for Gonzaga to cover.

Gonzaga’s offense is good enough to hang with Houston’s elite defense. The Bulldogs’ offense was clicking in their tournament opener against Georgia, as they scored 89 points and shot 60 percent from 3-point land. In anticipate another great offensive performance since they are among the most prolific and consistent teams at that end of the floor in 2024-25. According to KenPom, Gonzaga’s offense is ranked #7 in adjusted efficiency and #11 in 2-point percentage. The Zags should be able to be good enough to score even on Houston’s elite defense. I’m taking Gonzaga to cover.

Gonzaga vs Houston prediction: Gonzaga +5.5 (-110) available at time of publishing. Playable at that number.

You can bet on our Gonzaga vs Houston pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first wager is a winner!