Creighton Bluejays vs Auburn Tigers Prediction, Odds and Picks for Today, 03/22/25

The Creighton Bluejays and the Auburn Tigers will face off on Saturday evening in Lexington in the NCAA Tournament round of 32. Auburn is the #1 overall seed and advanced with a win over Alabama State, while Creighton is a #9 seed and ousted Louisville to get here. The Bluejays were 2.5-point underdogs in their win vs Louisville but had no trouble getting the job done. They made 11 threes and scored 89 points on Thursday, but I see them struggling to shoot that well again. The spread is 8.5 points favor of Auburn, and my Creighton vs Auburn pick is on the Tigers to cover.

I do not see Creighton’s offense having much success against Auburn’s great defense. The Tigers are one of the best teams in the country at limiting opposing teams’ 3s, which could be a major problem for the Bluejays. According to KenPom, Auburn’s defense is ranked #5 in 3-point percentage, #7 in effective field-goal percentage and #13 in adjusted efficiency. The Tigers boast one of the best defenses in the entire country and it should be too much for the ‘Jays to handle. I’m backing the Tigers.

Creighton vs Auburn prediction: Auburn -8.5 (-110) available at time of publishing. Playable to -9.

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