MLB Picks

The Cleveland Guardians and Washington Nationals meet Wednesday afternoon in the nation’s capital after splitting a rare interleague doubleheader between the teams Tuesday. Monday’s game was washed out due to thunderstorms in the capital region. Cleveland lost 10-9 in Game 1, before picking up a 9-1 victory in Game 2. Now, the Guardians turn to LHP Logan Allen to get the job done in the series finale. The Nationals have managed just a 2-4 record against left-hander starting pitchers so far this season. Washington is also just 3-5 in interleague games, while Cleveland is 4-4 in eight tries against the National League.

Despite the Game 1 setback, the Guardians are 3-1 in the past four games on the road, while going 6-2 across the previous eight contests. The Guardians also won Allen’s most recent appearance on the road against a NL opponent, the Pittsburgh Pirates, on April 20. They’re also 3-2 across his previous five outings, too. For the Nationals, they’ve allowed six or more runs in four of the past five games, and eight of the previous 10 contests. Look for Cleveland to rack up healthy totals against RHP Michael Soroka on getaway day. The latter is returning from the 15-day injured list due to a biceps injury, and he could have some rust.

Guardians vs Nationals prediction: Guardians ML (-135) available at time of publishing. Playable to -140.

You can bet on our Orioles vs Twins pick at DraftKings Sportsbook, which has thousands of betting options available and a great new customer offer where you can get $200 in bonus bets INSTANTLY when you make a first bet of just $5! Click here 👈🏼 to sign up for a DraftKings account now.

In this game, we will see the Pittsburgh Pirates take on the St. Louis Cardinals for the sixth time this year. So far, the Cardinals are leading the series 3 games to 2. Yesterday’s game was very close with the Cardinals winning 2-1, but both teams only had 4 hits. Hitting may continue to be a struggle as we will see Mitch Keller of the Pirates and Sonny Gray of the Cardinals. Keller has struggled in his recent starts where he has given up 24 hits and 11 runs in 22 innings pitched. On the other side, Gray is coming off his worst start of the year where he pitched 4.1 innings against the New York Mets giving up 9 hits and 4 earned runs. Both pitchers have faced off against the opposing team this year. Keller pitched 7.1 innings only giving up 4 hits and no runs against the Cardinals, while Gray pitched 5 innings, giving up 3 hits and 1 run against the Pirates.

On the hitting side, the struggles for the Pirates continue to rear their ugly head. Pittsburgh has only scored 118 runs on the year and rank 27th in batting average. The Pirates have also struggled away from home only scoring 52 runs on 128 hits with a batting average of .214. This is much different than the Cardinals as they rank 4th in batting average and have scored 169 runs this year. At home, the Cardinals have a batting average of .286 while scoring 96 runs on 191 hits. To top it all off, the Pirates are 5-13 away and the Cardinals are 14-6 at home. Given the bounce-back spot for Sonny Gray, the hitting struggles of the Pirates, and the impressive form of the Cardinals at home, I am taking the Cardinals on the run line.

Pirates vs Cardinals prediction: Cardinals -1.5 (+120) available at time of publishing. Playable at that number.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook. If you bet just $1, you’ll receive DOUBLE YOUR WINNINGS on your next 10 bets! Become a Caesars member 👥 using the Caesars promo code PWCONTENTDYW, where you can bet on our Pirates vs Cardinals picks.

In this game, we will see the San Francisco Giants take on the Chicago Cubs. Last night, the Giants won after scoring 9 runs in the 11th inning. With the previous game going 11 innings, we can expect that neither of these teams are looking to use their bullpen in this one. For today, we will see Robbie Ray of the Giants and Ben Brown of the Cubs take the mound. Ray has been great in his last 2 starts where he has gone 7 innings in each game. To top that off, he has only given up 7 hits and 2 runs in those 14 innings. Brown also pitched great in his last start going 6 innings giving up 4 hits and no runs. While that was a great start for him, he has not been so lucky at home this year. At home, he has pitched 11.2 innings giving up 12 runs on 19 hits. He is yet to make it longer than 4 innings in a home start.

On the hitting side, both teams have scored 41 runs on 62 hits in the last 7 days. We also saw the teams swap in the two previous games with the Cubs scoring 9 in the first game and the Giants scoring 14 in the second. Given the potential for both teams to hit the ball, our emphasis rides on the pitching in this one. For the starters, we can feel more confident in Ray who holds a 4-0 record with the Giants winning every game he has started this season. Additionally, the Giants bullpen has an ERA of 2.53 only giving up 35 runs this season. This is much different than the Cubs bullpen who has given up 70 runs this season (although last night did not help those numbers). Given Ray’s potential to go deep into the game, the shaky home form of Brown, and the elite bullpen of the Giants, we can suspect that the Giants take this one.

Giants vs Cubs prediction: Giants ML (+125) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Giants vs Cubs predictions.

After splitting the first pair of games, both the New York Mets and Arizona Diamondbacks look to take the series win this afternoon with a quality pitching matchup on the bump. Merrill Kelly (4.06 ERA, 1.06 WHIP) gets the start for Arizona, and the righty has been dominant ever since a 9 ER, 3.2 IP outing that inflated his numbers drastically. Since then, Kelly has surrendered only 7 ER in his last 28.2 IP. On the other side, Kodai Senga (1.38 ERA, 1.16 WHIP) gets the start for New York and he has been nothing short of incredible in 2025, posting some of the best numbers in the league.

With two starting pitchers well in form on the mound, we turn to the offenses as Arizona holds the slight advantage against right-handed pitching. The Diamondbacks rank 4th in wRC+ and 2nd in wOBA against RHP this season and the offense has posted 20 runs over the last three games. With all things considered, there is slight value on Arizona at the plus-money price and I’ll take the Diamondbacks to get the win.

Mets vs Diamondbacks prediction: Arizona ML (+105) available at time of publishing. Playable to -120.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Mets vs Diamondbacks predictions.

The Phillies kept their momentum going with an 8-4 win over the Rays on Tuesday night. Nick Castellanos played a huge role in the Phillies victory yesterday, going 3-for-5 and driving in four of the team’s eight runs. Looking ahead to tonight’s matchup, the Phillies will send the southpaw Cristopher Sanchez to the mound who is 3-1 with a 3.45 ERA, striking out 39 over 31.1 innings pitched. Seeing Sanchez start for the Phillies has to make the Rays a little nervous. The Rays have struggled against left-handed pitching this season, batting just .189 as a team. 

In hopes to steal a victory, the Rays will hand the ball over to Shane Baz who is 3-1 with a 3.86 ERA. In his last start, Baz struggled against the Royals, giving up seven earned runs on nine hits in just 5.2 innings pitched. Baz has a nasty curveball that can put away hitters, but if he’s unable to locate it, he could be in for a long day. The Phillies have an OPS of .745 and average 4.8 runs per game, and for the Rays, they have an OPS of .678 and average 3.9 runs per game. At the end of the day, I’m surprised this line isn’t more in favor of the Phillies. They are the better hitting team, and also have the advantage on the mound based on how the Rays have struggled against lefties this season. Look for the Phillies to roll in this matchup, making the Phillies money line my best bet of the day. 

Phillies vs Rays prediction: Phillies ML (-125) available at time of publishing. Playable at that number.

You can bet on our Phillies vs Rays pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!

The San Diego Padres enter Wednesday’s matchups against the Yankees as heavy underdogs with Dylan Cease (5.61 ERA, 1.60 WHIP) taking the mound for the visitors. The righty hasn’t surrendered more than 2 runs in four consecutive starts, and his 4.24 xERA suggests he is due to continue this trend of positive regression. He faces a tall task against what has clearly been the best offense in baseball this season, but the Yankees can certainly be outdueled. San Diego ranks 3rd in BA altogether this season and has already gotten the better of New York once this series.

Max Fried (1.01 ERA, 0.94 WHIP) gets the start for New York following three straight shutout performances. Fried has been incredible, but a 3.28 xERA suggests he can’t keep this up forever, especially against a capable offense like San Diego’s. The real advantage for San Diego comes in the bullpen, as the Padres’ unit holds the best combined ERA in baseball (1.73) and leads the league in saves (14). With all things considered, the price on San Diego is too good to pass up and I’ll back the Padres to take the series with a win today.

Padres vs Yankees prediction: San Diego ML (+150) available at time of publishing. Playable at that number or better.

We head to the Big A on Wednesday for a Cincinnati Reds vs Atlanta Braves prediction. The Braves have taken the first two games in this 4-game series, and the Braves are finally starting to heat up after their abysmal start to the season. The Reds, on the other hand, have now dropped 4 games in a row. This is just sort of what the Reds do—they go in streaks, and that happens with teams that are still very young. The last time the Reds won? Yep, it was when Hunter Greene was on the mound. Greene returns to the bump on Wednesday, and I think that will be enough to pick the Reds back up from their losing streak. My Reds vs Braves prediction is the Reds to win.

Greene has been incredible this season. Only once has he failed to fan at least 7 guys in a start, and that was a 3-inning dud at Baltimore. That was his only bad start on the season, and I expect him to stay dominant on Wednesday. He will face Grant Holmes, a guy who has been forced into the starting role, but who has been cautiously successful. He posted a quality start against the Dodgers last time out, but he’s not a guy I want to bank on consistently. The Cincy offense has been quiet thus far in the series, but I am betting they wake up with Greene on the mound. Be careful here because there is weather in the forecast, so you might want to wait to lock anything in, but my pick is for the Reds to take this one.

Reds vs Braves prediction: Reds ML (-115) available at time of publishing. Playable at that number.

You can bet on our Reds vs Braves pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!

The Baltimore Orioles were pounded 9-1 in the series opener at Target Field on Tuesday, dropping their third consecutive game. The O’s are a dismal eight games under .500, and a main reason for the struggles has been their inability to win on the road. Baltimore is just 5-12 away from Charm City, and it has dropped four in a row, and the Orioles are 1-8 in the past nine games away from home. RHP Charlie Morton was briefly moved to the bullpen since April 20, but the struggling veteran returns to a starting role. He has a dismal 0-6 record, 9.76 ERA and 2.20 WHIP this season.

The Minnesota Twins have won three straight games, and the nine runs scored in Tuesday’s opener was the most at home since April 25 when they played 11 runs against the Los Angeles Angels. The Halos have scored four in a row at home, and eight of the past nine games. These are two teams going in completely different directions. Bank on the Twins at home, and keep fading the struggling veteran Morton until he shows signs of turning things around.

Orioles vs Twins prediction: Twins ML (-130) available at time of publishing. Playable to -160.

You can bet on our Orioles vs Twins pick at DraftKings Sportsbook, which has thousands of betting options available and a great new customer offer where you can get $200 in bonus bets INSTANTLY when you make a first bet of just $5! Click here 👈🏼 to sign up for a DraftKings account now.