NFL Best Bets

Get our experts’ best NFL bets every week of the 2024/25 season. Our experts analyze their NFL picks and predictions across a whole host of markets to find you their best NFL Bets every week, right here.

Pickswise’s NFL Best Bets went 66-43 for +45 Units of profit throughout the 2023/24 NFL Season.

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Dallas Cowboys
Tomorrow
Washington Commanders
Point Spread PickBest Bet
DAL Cowboys +10.0(-110)DAL Cowboys @ WAS Commanders

We have a classic rivalry showdown here in the NFC East this week as the Washington Commanders get ready to host the Dallas Cowboys. A couple years ago it would have sounded crazy to say the Commanders would be one of the toasts of the league while the Cowboys would be a laughingstock, but that’s where we’re at. Dallas is in free-fall in the wake of Dak Prescott’s injury and it is coming off a blowout loss at home to the Texans.

I think there is value in buying low on the Cowboys. We are getting them at their absolute rock-bottom price in the market after the spanking on national TV at the hands of Houston that everyone saw, but it’s important not to overreact. This is a division game that’s going to be hard-fought, and getting double-digits is too good of an opportunity to pass up. I also just think Washington is a bit overrated. The Commanders are 3-3 in their last 6, and that figure gets worse when you dig into it. Their 3 wins in that span? They have come against the Giants, Panthers and Bears. New York and Carolina might be the 2 worst teams in the league and Chicago hasn’t looked much better of late. And even the Bears they only beat on a last-second, walk-off Hail Mary.

Jayden Daniels has quietly come back down to Earth following his red-hot start, and over his last 2 games he has just 1 touchdown while averaging fewer than 6 yards per attempt. Even against the G-Men, the Commanders only managed to win by 5 in a game that came down to the wire after they almost choked to Daniel Jones. As such, I don’t see any reason to feel good about laying double-digits with them on Sunday. The Cowboys have also played much better on the road this year; they are 0-5 at home but 3-2 on the road.

Cowboys vs Commanders prediction: Cowboys +10 (-110) available at time of publishing. Playable at that number.

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Andrew Ortenberg
Detroit Lions
Tomorrow
Indianapolis Colts
Point Spread PickBest Bet
DET Lions -6.5(-120)DET Lions @ IND Colts

The Detroit Lions will be looking to solidify their new status as Super Bowl favorites when they visit the Indianapolis Colts on Sunday afternoon. That’s right; the Detroit Lions are favored to win the Super Bowl. They assumed the top spot for the first time this season — and first time in franchise history — following this past week’s 52-6 humiliation of the Jacksonville Jaguars that coincided with the Kansas City Chiefs’ first loss. And it’s hard to argue with the odds. Detroit is an absolute wagon from an offensive standpoint. Jared Goff bounced back from his interception barrage in Week 10 by torching Jacksonville for 412 yards and 4 touchdowns on 25-of-29 passing. Amon-Ra St. Brown (2), David Montgomery (2) and Jahmyr Gibbs (1) scored at least 1 touchdown in the same game for the 8th time in their careers — already a record for 3 teammates in the history of the NFL.

Indianapolis +3.5 against the New York Jets was a 3-star best bet winner for me in Week 11, but I’m prepared to fade the Colts this time. After all, facing the Lions is the most opposite extreme you can possibly get compared to facing the Jets. Indy squandered all of a 13-0 lead over the Jets before recovering late, so that really doesn’t inspire much confidence. Jonathan Taylor averaging just 2.4 yards per carry in that game also isn’t encouraging. What’s even more worrying is that the Colts rank 26th in the league against the pass and 25th in opponents’ yards per pass attempt. How do you think they are going to stop Goff, St. Brown and the rest of the gang? I would be more than happy to play this at -7.5, which you can get at plus money (+100) at time of publishing. However, at less than a touchdown (and PAT) it evokes max confidence. The Lions should continue to roll.

Lions vs Colts prediction: Lions -6.5 (-120) available at time of publishing. Playable to -7.5 (+100).

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Ricky Dimon
Minnesota Vikings
Tomorrow
Chicago Bears
Game Totals PickBest Bet
Under 39.5(-110)MIN Vikings @ CHI Bears

My main Vikings vs Bears prediction for Sunday is for this NFC North matchup to be an absolute slog. While I did like what I saw from Chicago’s newly appointed playcaller Thomas Brown last weekend against the Packers, going up against a Brian Flores-led defense will be a different animal. Minnesota is blitzing opposing QBs at a 37.7% clip (1st in the NFL) this season, and the Vikings have caused fits for young quarterbacks. Minnesota has faced Daniel Jones, Brock Purdy, C.J. Stroud, Jordan Love, Mac Jones and Will Levis this season, and only Love and the Packers had success in a 31-29 defeat. However, the other 5 QBs managed to lead their offense to an average of just 10.5 points, and even if you add in the Packers’ high-scoring game, that average only goes up to 13.1 points.

On the flip side, the Bears’ defense has been one of the lone bright spots for this Chicago team. In their 6 home games, the Bears have allowed an average of 16.7 points per contest, and no team has scored more than 20 points at Soldier Field. Additionally, Minnesota’s offense has sputtered in recent weeks after their hot start, and they’ve tallied just 21.0 points per game since their bye week. The hosts have done a great job containing opposing QBs at home this season, as only Jordan Love has thrown for more than 250 yards while facing the Bears in Chicago.

The Bears allow just 18.7 points per game (7th in the NFL), while the Vikings give up 17.0 (4th in the NFL). Chicago has seen each of their last 4 games finish Under while Minnesota’s last 3 contests finished Under as well. Additionally, the previous 5 meetings at Soldier Field between these squads finished Under the total. I expect all 3 trends to continue this Sunday and will back the Under in this NFC North rock fight. 

Vikings vs Bears prediction: Under 39.5 (-110) available at the time of publishing, playable down to 38.5 (-110).

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Luke Lindholm
Denver Broncos
Tomorrow
Las Vegas Raiders
Game Totals PickBest Bet
Under 41.0(-110)DEN Broncos @ LV Raiders

I also like the under in what should be a low-scoring affair. There is no love lost between these teams that are super familiar with one another, and they just played a handful of weeks ago. We have got a rookie quarterback on one side and Gardner Minshew on the other, so I’m not expecting a shootout. Bo Nix has made strides from his first couple of starts, but he’s still not great when the circumstances around him aren’t perfect. Before the explosion last week against Atlanta, Denver’s offense had failed to top 14 points in back-to-back games.

The Raiders, on the other hand, have very few weapons after trading away Davante Adams — and Brock Bowers can’t do it all by himself. Las Vegas has only scored more than 20 points once in its last 7 games, so I think the Broncos will be pretty conservative on offense knowing they can likely rely on their defense. Last week Denver held Atlanta’s usually productive offense to just 6 points and they made Kirk Cousins struggle while shutting down Bijan Robinson on the ground.

Denver Broncos vs Las Vegas Raiders prediction: Under 41 (-110) available at time of publishing. Playable to 40.

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Andrew Ortenberg
Baltimore Ravens
Mon Nov 25
Los Angeles Chargers
Point Spread PickBest Bet
BAL Ravens -3.0(-105)BAL Ravens @ LA Chargers

The “Harbaugh Bowl” has returned as John’s Ravens will travel across the country to take on Jim’s Chargers. Baltimore is coming off a loss that has NFL analysts shifting their opinions (again) on their potential, while the Chargers are off a huge win on Sunday night, holding off a melee by Joe Burrow and the Bengals. The market typically overreacts to these week-to-week situations, but we are encouraged to see that Baltimore is still getting the respect they deserve. We will argue they should get even more. Watching the Chargers this season proves how coaching can make a huge difference in football. Jim Harbaugh’s program is 7-3, competitive with the Chiefs in the AFC West, and they already have one of the NFL’s best defenses. Harbaugh has inherited a very talented roster on that side of the ball and he’s made the most out of it. And despite criticisms of the Bolts’ shallow wide-receiver depth chart, they’re doing plenty to win games (8th in yards/pass, 7.9). There is one area where the Chargers have consistently been a letdown all season, though – their run defense.

LA’s defense has mostly been terrific, but 11 weeks in they’re still allowing 4.7 yards per rush, a bottom-10 mark in the league (23rd). All year, good running teams have succeeded against the Chargers: Pittsburgh (114), Kansas City (110), Arizona (181) and Tennessee (157) to name a few. This is not great news with Derrick Henry and the Ravens coming to town, an offense that averages 5.8 yards/rush (1st) and 177.3 rush yards/game (2nd). On top of that, the Ravens are off a very emotional loss. Lamar Jackson is facing his share of criticism once again, with pundits and analysts claiming he cannot win “the big game” after another collapse against his rival. We’re not here to argue either way, but Sunday night does not qualify as a similar spot. The Ravens are angry, while the Chargers are probably a little too fat and sassy after surviving against Cincinnati and winning 4 straight. We like Baltimore to go off on Monday Night Football.

Ravens vs Chargers prediction: Ravens -3 (-105) available at time of publishing. Playable at that number.

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Chris R. Farley
NFL Best Bets
51.6%
Win %
33Wins
31Losses
0Pushes
Percentage only includes Wins and Losses

NFL Video

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, and we bring you free NFL best bets across the whole season and post-season.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers, post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details just that, our expert NFL Best Bets on this week’s games.

How Did Pickswise’s NFL Best Bets Perform Last Season?

The expert NFL handicappers at Pickswise saw great success throughout the 2023/24 NFL season and their best bets were no different. We post multiple best bets each week of the season, all accompanied by analysis, data and trends that are all fact-checked by our editors. Check out our 2023/24 NFL Best Bets records below;

2023-24 NFL Best Bets Record
WinLossProfit/Loss
6643+45 Units

NFL Best Bets Today

The NFL action comes thick and fast during the season and we cover all of it. The NFL Best Bets page should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best Bets For NFL This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different. You can often find great value early in the week and our experts will take an early look ahead every week, and aim to get our best bets for NFL this week posted on-site as soon as possible, to try to lock in those best lines and odds. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over time.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


+45 Units from 2023/24 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2023 season, our team of expert NFL handicappers finished +45 units in profit on our best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets saw a return of +45 units across the 2023/24 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.

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