Real Madrid vs Arsenal Prediction, Odds and Picks for Today, 04/16/25

Arsenal scored 3 2nd-half goals to secure a 3-0 1st-leg lead over Real Madrid in the Champions League quarterfinals last week, and more fireworks are expected when the 2 meet at the Bernabeu Stadium on Wednesday. Declan Rice’s stunning pair of free kicks set the Gunners on their way before Mikel Merino completed the scoring, leaving Los Blancos with a mountain to climb if their Champions League defense is to continue.

What we can expect on Wednesday is both teams to have plenty of attacking opportunities, with the hosts needing to go on the front foot early in an attempt to reduce the first-leg deficit and change the complexion of the tie. However, that could leave Real Madrid vulnerable in defense, and shutouts have been hard to come by at the Bernabeu lately. Both teams have scored in 10 of their last 11 competitive games here, and Arsenal’s last 3 on the road have featured goals at both ends, making that a standout pick for Wednesday.