San Francisco 49ers vs Tampa Bay Buccaneers Prediction, Odds and Picks for Sunday, 11/10/24
WLWLW | Last 5 | LWLLL |
| 4-4 | Record | 4-5 |
| 4-4-0 | ATS Record | 5-4-0 |
| 4-4 | O/U Record | 7-2 |
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The San Francisco 49ers will travel to the East Coast for a matchup against the Tampa Bay Buccaneers, and I’m expecting a big win for the visitors. The 49ers have been plagued with injuries to their skill positions this season, as Christian McCaffrey, Deebo Samuel and Brandon Aiyuk have all missed multiple games, with the latter out for the season. However, CMC was a limited participant in practice on Wednesday, and if he plays this Sunday, San Fran should win by 10+. The Niners enter this game off a bye week, and Kyle Shanahan’s men are 4-1 in their last 5 games following a bye. Not only do they have an extra week of rest, but Tampa Bay enters this contest after a tough overtime defeat against the Kansas City Chiefs, and it feels like the wheels are starting to fall off for the Bucs.
Tampa Bay has its own injury crisis, as WR Chris Godwin suffered a season-ending ankle injury 2 weeks ago and Mike Evans is still nursing a hamstring injury. Evans’ status for Sunday is ominous, as he didn’t practice on Wednesday, and WRs Jalen McMillan and Sterling Shepard were also absentees. Outside of TE Cade Otton, I’m not sure who QB Baker Mayfield can target this Sunday, and even RB Bucky Irving was a limited participant on Wednesday. They showed tremendous grit fighting back in Kansas City last week to force overtime, but they came up short and have now lost 3 straight contests by an average of 7 points.
Both teams are entering must-win territory this season, but the Bucs’ playoff chances are much lower than San Francisco’s given that they’ve already dropped both games against the Falcons this season. Additionally, QB Brock Purdy has had plenty of success traveling to the East Coast, as he is 4-1 in his career with an average win margin of 23.5 points in the 4 victories. The 49ers still have to play the Bills, Lions and Packers down the stretch, so this game feels like a must-win, and I’ll gladly back the 49ers to win by 7+ at Raymond James Stadium.
49ers vs Buccaneers prediction: San Francisco -6 (-110) available at the time of publishing, playable down to -6.5 (-125).
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49ers vs Buccaneers Pickswise Expert Predictions
Luke Lindholm
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The 49ers have won 4 of their last 5 matchups against NFC South teams
The Buccaneers have lost 3 straight games after a 4-2 start.
4 of the Buccaneers' last 5 home games have gone Over the total.
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