San Francisco 49ers

San Francisco 49ers vs Tampa Bay Buccaneers Prediction, Odds and Picks for Sunday, 11/10/24

Raymond James StadiumFOX
49ers
49ers
Sun Nov 10
Buccaneers
Buccaneers
WLWLW
Last 5
LWLLL
4-4Record4-5
4-4-0ATS Record5-4-0
4-4O/U Record7-2
Tampa Bay Buccaneers

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San Francisco 49ers
NFL
Tampa Bay Buccaneers
Point Spread PickBest Bet
SF 49ers -6.0(-110)SF 49ers @ TB Buccaneers

The San Francisco 49ers will travel to the East Coast for a matchup against the Tampa Bay Buccaneers, and I’m expecting a big win for the visitors. The 49ers have been plagued with injuries to their skill positions this season, as Christian McCaffrey, Deebo Samuel and Brandon Aiyuk have all missed multiple games, with the latter out for the season. However, CMC was a limited participant in practice on Wednesday, and if he plays this Sunday, San Fran should win by 10+. The Niners enter this game off a bye week, and Kyle Shanahan’s men are 4-1 in their last 5 games following a bye. Not only do they have an extra week of rest, but Tampa Bay enters this contest after a tough overtime defeat against the Kansas City Chiefs, and it feels like the wheels are starting to fall off for the Bucs.

Tampa Bay has its own injury crisis, as WR Chris Godwin suffered a season-ending ankle injury 2 weeks ago and Mike Evans is still nursing a hamstring injury. Evans’ status for Sunday is ominous, as he didn’t practice on Wednesday, and WRs Jalen McMillan and Sterling Shepard were also absentees. Outside of TE Cade Otton, I’m not sure who QB Baker Mayfield can target this Sunday, and even RB Bucky Irving was a limited participant on Wednesday. They showed tremendous grit fighting back in Kansas City last week to force overtime, but they came up short and have now lost 3 straight contests by an average of 7 points.

Both teams are entering must-win territory this season, but the Bucs’ playoff chances are much lower than San Francisco’s given that they’ve already dropped both games against the Falcons this season. Additionally, QB Brock Purdy has had plenty of success traveling to the East Coast, as he is 4-1 in his career with an average win margin of 23.5 points in the 4 victories. The 49ers still have to play the Bills, Lions and Packers down the stretch, so this game feels like a must-win, and I’ll gladly back the 49ers to win by 7+ at Raymond James Stadium.

49ers vs Buccaneers prediction: San Francisco -6 (-110) available at the time of publishing, playable down to -6.5 (-125).

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Luke Lindholm

49ers vs Buccaneers Pickswise Expert Predictions

San Francisco 49ers
NFL
Tampa Bay Buccaneers
Game Totals Pick
Under 51.0(-110)SF 49ers @ TB Buccaneers

I expect this game to come down to the wire when it comes to the total, but I don’t think Tampa Bay will put up enough points for this game to go over. As I stated in my side prediction, this Buccaneers offense is decimated, and even though they combined for 54 points with the Chiefs on MNF last week, 37 of them came in the second half and overtime. Now they could be without WR Sterling Shepard, who contributed 69 total yards of offense last week. Not only that, but they’re going against a 49ers defense that allows just 314.8 yards (10th in the NFL) and 22.8 points per game (16th in the NFL) with an extra week of rest.

On the flip side, I do think San Francisco will put up points, but they’ve been hit or miss when it comes to scoring this season. The 49ers have scored 24 or fewer points in ½ their games this season, and even in their games where they scored more than this mark, the total finished with 54, 60, 43 and 51 points (52.0 points on average). So, even if the 49ers score 30+, Tampa Bay will need to contribute 21+ for this game to go over, which would be a big surprise. The Bucs have played well at home this year, but that was mainly due to strong contributions from WRs Mike Evans and Chris Godwin. This will be their first home contest without their elite WR duo, so they’ll need to lean on TE Cade Otton and their rushing attack. Unfortunately for them, San Francisco is giving up 38.3 yards per game to tight ends and allows just 105.8 rushing yards per contest (6th in the NFL).  5 of the last 6 meetings between these squads in Tampa Bay finished Under, and this Buccaneers offense is just too beat up to expect them to put up points, so I’ll take the Under here.

49ers vs Buccaneers prediction: Under 51 (-110) available at time of publishing, playable down to -120.

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Luke Lindholm
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Luke Lindholm

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Luke Lindholm is the Managing Editor of US Media Partnerships for Spotlight Sports Group (SSG) and is living in Boston, Massachusetts. Luke has been handicapping NCAAF and Soccer for more than five years and loves sharing knowledge with other knowledgeable handicappers in the sports betting industry. For Luke Lindholm media enquiries, please email contact@pickswise.com.
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Top Trends
Money Line

The 49ers have won 4 of their last 5 matchups against NFC South teams

Money Line

The Buccaneers have lost 3 straight games after a 4-2 start.

Game Totals

4 of the Buccaneers' last 5 home games have gone Over the total.

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Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $200 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at sportsbook.draftkings.com.

Caesars Sportsbook

$1,000

$1,000 First Bet on Caesars

Sign up for a new Caesars Sportsbook account and Place your 1st wager of $10 or more

Place your first wager up to $1,000

If the bet losses, earn a a one-time Bonus Bettoken equal to the qualifying wager

21+. New users and first wager only. See Caesars.com/promos for full terms. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER. MA: CALL 1-800-327-5050 NY: Call 877-8-HOPENY or text HOPENY (467369)

bet365

$1,000

Bet $5 and Get $150 in Bonus Bets OR $1,000 Back If Your First Bet Loses

Register for a new bet365 account

Place $5+ and get $150 in bonus bets - no matter if your bet wins or loses

OR $1,000 back in bonus bets if your first bet loses

Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in OH, CO, NJ, VA, IA, KY, LA, AZ, IN. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer. Deposit required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers only. T&Cs, time limits and exclusions apply

Underdog Fantasy

$1,000

First Time Deposit Offer up to $1,000 in Bonus Cash

Sign up for a new account with Underdog Fantasy

Make your first deposit up to $1,000

Get a 100% deposit match, and new users can get up to $1,000 in bonus cash on their first deposit

Must be 21+ to play. Terms & conditions apply

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