San Francisco 49ers vs Los Angeles Rams Prediction, Odds and Picks for Sunday, 09/22/24
WWLWL | Last 5 | WWLLL |
1-1 | Record | 0-2 |
1-1-0 | ATS Record | 0-2-0 |
1-1 | O/U Record | 1-1 |
49ers vs Rams Pickswise Expert Predictions
This is a game where I would’ve had a much stronger opinion a week ago, but circumstances have changed since each of these teams last took the field. Historically, Kyle Shanahan has dominated this coaching matchup against Sean McVay, and I was anticipating that we’d get a number closer to the lookahead line of San Francisco -4, which would’ve put me on the Niners in a dream spot following their loss to the Vikings in Minnesota. Instead, we’ve gotten disconcerting injury news for both teams over the last few days, as San Francisco will be without both Christian McCaffrey and Deebo Samuel for this game, while the Rams are down Cooper Kupp, Puka Nacua and a whole host of starters on the offensive line. The Rams’ defense is also a major issue, as Los Angeles is set to be without three of its starting defensive backs in the secondary. We saw how those injuries impacted the Rams in last week’s blowout defeat at the hands of Kyler Murray and the Cardinals, and I wouldn’t expect things to get much better against a 49ers offense that surprisingly leads the league in passing yards through 2 weeks.
San Francisco was a team that had major questions on its offensive line heading into the season, but Trent Williams and company have held up over the course of the first couple of weeks of the season. Running back Jordan Mason should have another strong game in his third consecutive start, as the Rams defense ranks inside the bottom 5 of the league in adjusted line yards. The 49ers’ offensive line also boasts one of the best sack rates in the league, so Brock Purdy should have time to sit in the pocket and pick apart this depleted defense. The same can’t be said for Matthew Stafford on the other side, who is playing behind a makeshift offensive line that could be in real trouble this weekend. My best bet for this game would be to put the 49ers as one leg in a 6-point, 2-team Wong Teaser (preferably with the Chargers or Bengals), as we’re getting San Francisco through the key numbers of 3 and 7 here. With that said, I’ll still lay the points in this spot for my 49ers vs Rams best bet.
49ers vs Rams prediction: 49ers -7 available at time of publishing. Playable at that number.
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Model projections coming soon
The 49ers are 4-1 against the spread in their last 5 road games.
The 49ers' last 3 games against the Rams have gone over the total.
The 49ers have won 4 of their last 5 road games against teams with losing records.
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