San Francisco 49ers vs Buffalo Bills Prediction, Odds and SNF Picks for Sunday, 12/01/24
LWWLL | Last 5 | WWWWW |
| 5-6 | Record | 9-2 |
| 4-7-0 | ATS Record | 7-4-0 |
| 5-6 | O/U Record | 7-4 |
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Things just seem to be getting worse for the 49ers. One week after a shocking loss to the Seahawks at home, where they allowed their rival to go up 20-17 late in the 4th quarter after leading for the entire game, San Francisco got pounded by the Packers at Lambeau Field in Week 12. Of course, they were without their starting QB, Brock Purdy, but a struggling 49ers’ defense couldn’t stop the Packers rushing attack at any point in the contest (169 yards), while a healthy Christian McCaffrey and company only managed 44 yards on the ground (and just 10 points). To some, the return of McCaffrey signaled a potential playoff run for last year’s NFC champion, but it’s had more of a negative impact if anything. McCaffrey clearly isn’t in football shape; he lacks the explosiveness we’re used to seeing from him, and he’s only averaging 3.5 yards per carry. Jordan Mason, on the other hand, is averaging 5.1 ypc. What’s more – the Niners’ offense is averaging just 16.7 ppg with their star RB back in the lineup, a sign that his presence has felt forced and that his team is desperate for some sort of improvement.
And it might get even more negative after Week 13. Following an embarrassing loss at Green Bay, the Niners must travel across the country to clash with the Bills at one of the toughest venues in the NFL. Orchard Park, NY will be rocking in support of their team, a program that’s going in the complete opposite direction of their opponent on Sunday night. The Bills have won 6 straight games and they’re 5-0 at home. In their last 6 wins, which included impressive victories over the Seahawks, Dolphins and Chiefs, Buffalo has outscored opponents by an average margin of 11.6 ppg. Josh Allen has been playing at an MVP level during the latest stretch, throwing 10 TDs and just 4 interceptions while running for 156 yards and another 3 TDs. Their defense, which incurred early injuries and looked a bit underwhelming to start the season, has stepped up and shown the same vigor that we’ve come to expect from a Sean McDermott-led unit. They’re 7th in opponent ppg, 10th in opponent red-zone TD rate and 8th in opponent yards per pass.
Unfortunately for the road team and last year’s Super Bowl loser, Brock Purdy’s shoulder injury is very concerning. He practiced in very limited fashion on Tuesday, and coach Kyle Shanahan is being elusive about his status. This does not profile as a good situation for the 49ers, who are also facing Buffalo after their bye week. It’s Bills or nothing in this one.
49ers vs Bills prediction: Bills -7 (-105) available at time of publishing. Playable at that number.
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49ers vs Bills Pickswise Expert Predictions
Chris Farley
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The Bills' last 3 games have gone Over the total.
The 49ers are 7-3 ATS in their last 10 games as a road underdog.
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