New England Patriots vs San Francisco 49ers Prediction, Odds and Picks for Sunday, 09/29/24
LLWLL | Last 5 | WLWLL |
| 1-2 | Record | 1-2 |
| 1-1-1 | ATS Record | 1-2-0 |
| 1-2 | O/U Record | 2-1 |
Patriots vs 49ers Pickswise Expert Predictions
The 49ers are severely banged up and it’s only Week 4. Last week, the 49ers were without Christian McCaffrey, Deebo Samuel and George Kittle on offense. That left Brock Purdy with Jordan Mason, Jauan Jennings and Brandon Aiyuk, but it wasn’t enough. The Niners lost to the Rams, who have also been decimated by injuries since they were without Cooper Kupp and Puka Nacua. If the 49ers lost to a Rams team that was without their 2 best offensive weapons and own one of the worst defenses in the league, there is a serious problem in San Fran. The 49ers’ injury report only grew after their Week 3 loss as Brock Purdy has been listed with a back injury. The Niners are fortunate to have a full week to rest before their next game against the Patriots, but they still won’t be at full health. McCaffrey is out for the next few weeks, Deebo is still questionable and hasn’t practiced yet and Shanahan said he’s hopeful that Kittle can return to practice sometime this week. If Kittle, Deebo or Purdy miss Week 4, this spread will likely shrink from 10 to below a touchdown.
It’s starting to look like New England’s Week 1 win over the Bengals wasn’t all that impressive. That’s because the Patriots have lost both games since and Cincinnati is still looking for their first win. The Pats were embarrassed last week on Thursday Night Football as they lost 24-3 to Aaron Rodgers and the Jets. There weren’t a lot of positives to take away from the game considering Jacoby Brissett didn’t even reach 100 passing yards and was sacked 7 times. The defense also got beat up by Breece Hall on the ground and Garrett Wilson through the air, so the Patriots couldn’t get out of MetLife Stadium fast enough. However, the one advantage the Patriots have in this game is health. New England has very few injuries and should be able to stick to their game plan on Sunday. This spread is likely going to fluctuate a lot this week based on San Francisco’s injury news, so keep an eye on the latest reports as the game gets closer. But right now, the Patriots have value as 10-point underdogs.
Patriots vs 49ers prediction: Patriots +10 (-110) available at time of publishing. Playable at that number.
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Kevin Davies
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Model projections coming soon
The Over is 4-1 in the 49ers' last 5 games.
The 49ers are 3-7 ATS in their last 10 games as a home favorite.
The 49ers have won their last 3 games at home, while the Patriots have lost 5 of their last 7.
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