Los Angeles Rams

Los Angeles Rams vs San Francisco 49ers Prediction, Odds and TNF Picks for Today, 12/12/24

Levi's StadiumAmazon Prime Video
Rams
Rams
Today
49ers
49ers
LWLWW
Last 5
WLLLW
7-6Record6-7
6-7-0ATS Record5-8-0
7-6O/U Record6-7

Vote on who will cover the spread!

San Francisco 49ers

Best Bets

Los Angeles Rams
NFL
San Francisco 49ers
Point Spread PickBest Bet
SF 49ers -2.5(-115)LA Rams @ SF 49ers

The Rams and 49ers both looked better coming out of Week 14. San Francisco finally got a desperately needed win in a dominant performance over the Bears, a program many sharp bettors supported in Week 14 following the firing of Matt Eberflus. Instead, it was San Francisco who came out fiery from the opening kickoff, out-gaining Chicago an astounding 309-4 in first-half total yards. They cruised to a 38-13 victory and immediately installed themselves back into the NFC West playoff picture, just 2 games behind the Seahawks. There are no easy contests left on their schedule (Rams followed by Dolphins, Lions and Cardinals), but they must win out to have any shot at another Super Bowl appearance. Needless to say, motivation will continue to be sky-high in the Bay Area and the spot is much better for the Niners since they remain at home on a short week.

The Rams were very impressive, too. Matthew Stafford led a calculated offensive attack, with Puka Nacua shining on his way to 12 catches, 162 yards and a touchdown, to stack up 44 points, outracing the Bills by 2 points in a highly entertaining battle. Their defense didn’t have much impact, especially in the second half, where they permitted 314 yards and 28 points. Still, the Rams’ offense can be so lethal that it feels like they can keep up with anyone, although they’ve certainly had their challenges against their divisional rival.

The Rams beat the 49ers in late September, which has become a rather atypical result. Since October 2019, the 49ers have defeated the Rams in 9 of their last 11 meetings in the regular season. It’s too early to tell, but there’s a chance that San Francisco gets back a few stars for TNF, including Trent Williams, Nick Bosa and Dre Greenlaw. Any one of those guys would be a significant addition and could mean that the spread increases if any are ready to suit up. We also love the revenge angle for the home team. Getting under the key number of “3” on a historic winner in these situations is enough for us to fire and ride the home team in this one.

Rams vs 49ers prediction: 49ers -2.5 (-110) available at time of publishing. Playable to 3.

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Chris R. Farley

Rams vs 49ers Pickswise Expert Predictions

Los Angeles Rams
NFL
San Francisco 49ers
Game Totals Pick
Under 49.0(-110)LA Rams @ SF 49ers

The Rams and 49ers looked like offensive juggernauts last week and the market has responded. The lookahead on the game was 47, a key number in sports betting and the 6th-most common ending total in the NFL in the last 10 seasons. It has moved up a full 2 points to 49 since Sunday. We don’t agree with that sentiment.

Firstly, the 49ers’ defense has one very clear weakness: limiting running backs. They have a terribly difficult time stopping opponents in the red zone (30th in rush TDs allowed per game), and as a former Super Bowl participant, they allow far too many yards per game (116). Rams runner Kyren Williams has come on strong lately, earning 5 yards per carry and 4 touchdowns in his last 4 games. LAR would be wise to burn clock and play keep-away from a San Francisco offense that was clicking on all cylinders last Sunday, and more rushing means more running clock.

This is also a divisional game, one that has huge consequences in the NFC playoff race, and both defenses are well aware that their rival’s offense looked impeccable in Week 14. Even with a lackluster run defense, San Francisco is still a formidable unit, top-6 in opponent yards and points per game. And there’s a chance that 2 defensive stalwarts, Nick Bosa and Dre Greenlaw, may return on Thursday Night Football. 7 of the last 10 matchups between these 2 enemies have gone Under this listed number and we project this one will too.

Rams vs 49ers prediction: Under 49 (-110) available at time of publishing. Playable to 48.5.

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Chris R. Farley
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Chris Farley

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Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.
Read more about Chris Farley

Same Game Parlay

Point Spread
SF 49ers -3.0
Player Receiving Yards
D. Samuel (SF) - 60+ rec yds
Anytime Touchdown Scorer
K. Williams (LAR) to score a TD

San Francisco 49ers -3 over LA Rams (+100) 

The 49ers got bogged down in the snow at Buffalo earlier this month, but they bounced back to completely blast the Chicago Bears amidst more normal circumstances in Week 14. San Francisco rolled 38-13 while out-gaining Chicago by an utterly ridiculous 309-to-4 margin in the first half. It was an encouraging performance without Christian McCaffrey, which is pretty much the life San Fran has been living all year long and will continue living the rest of the way.

The Rams are playing well, too, but this is a relatively 1-dimensional squad that is all offense and no defense. If the Niners’ defense comes to play (and Nick Bosa and Dre Greenlaw could be back), this is the more well-rounded team of the 2. The 49ers have won 9 of the last 11 regular-season meetings in the head-to-head series; don’t be surprised if they make it 10 of 12.

Deebo Samuel to record 60+ receiving yards (+135)

Deebo Samuel has not been getting the ball a ton in 2024 and has made no secret about his disdain over a lack of production. A since-deleted social media post wasn’t deleted fast enough, so everyone is well aware of Samuel’s griping. “Everyone” presumably includes Purdy, who will be delivering the ball in conditions that are expected to be sloppy. Although that points toward a run-heavy game script, quick passes to slot receivers are also a good idea. It is true that Samuel has been a non-factor of late, but he has reached the 60 mark 4 times this season and has come close to it 2 other times. The Rams rank 24th in the NFL against the pass and allow the 2nd-most yards per pass attempt, so the former South Carolina standout should be in line for a productive night.

Kyren Williams to score a touchdown (-170)

At the very least the field will likely be soaked; it could be a downpour during the game, as well. Whatever the case, keeping the ball on the ground for the most part would seem to be a prudent play. Regardless of the weather conditions, Los Angeles boasts a sizable advantage in the interior of the offensive line. San Francisco has allowed the 2nd-most rushing touchdowns in the NFL (19, tied with the Carolina Panthers), so Kyren Williams has every reason to score a TD on Thursday. These 2 division rivals faced each other in Week 3 and the Notre Dame product scored a whopping 3 times. Asking him to reach paydirt just once in this game should not be too much.

Ricky Dimon

Pickswise Expert Prop Picks

Los Angeles Rams
Player Rushing Yards Pick
K. Williams (LAR) - Over 71.5 rush yds(-110)

The rain shouldn’t be a factor Thursday night, but the potential for a soggy field could impact the aerial assault from both sides. For LA, they have a clear advantage here across the interior offensive line and I think they lean heavily on that early on. In the Week 3 matchup against San Francisco, Williams carried the ball 24 times for 89 yards. While the Rams did not have Cooper Kupp or Puka Nacua in that matchup, it will behoove Sean McVay to establish the run game on Thursday Night Football.

Over the last 3 weeks, we’ve seen James Cook rush 14 times for 107 yards, Ray Davis rush 11 times for 63 yards and Josh Jacobs rush 26 times for 106 yards. It will be worth monitoring Nick Bosa’s status for Thursday night as his absence has aligned perfectly with the uptick in recent rushing performances against San Francisco. He is currently questionable and did not practice on Tuesday with an oblique injury.

San Francisco 49ers
Bobby Stanley Jr. (PropHolliday)
Los Angeles Rams
Anytime Touchdown Scorer Pick
J. Jennings (SF) to score a TD(+160)

The 49ers’ offense exploded last Sunday against the Chicago Bears — primarily their passing game. Brock Purdy threw for 325 yards and 2 touchdowns, both going to Jauan Jennings. So naturally, we’re backing Jennings coming into Thursday with the 49ers as home favorites. San Francisco has question marks in their running game, which I want to avoid as a hole. Patrick Taylor and Isaac Guerendo are both at -140 to score a touchdown at FanDuel Sportsbook — a price I’m not willing to back. Jennings and Purdy have built a rapport that’s worth investing in. Jennings has scored 6 touchdowns this season, coming off an 8-target game, and 7+ in 4 of his last 5 games. With Deebo Samuel continuing to underwhelm, Jennings feels like the safer play at a better price.

San Francisco 49ers
jutpicks
Justin Martin (JutPicks)
Los Angeles Rams
Anytime Touchdown Scorer Pick
P. Nacua (LAR) to score a TD(+130)

Is it ridiculous to put Puka Nacua in the same conversation as Justin Jefferson and Ja’Marr Chase? He continues to turn heads week after week. Last Sunday, Nacua put on a show in primetime against the Bills. He scored 2 touchdowns, 1 on the ground and 1 through the air. He carried the ball 5 times and reeled in 12 of his 14 targets. He had mind-blowing catches on the sideline and continues to be Matthew Stafford’s #1 target when in a negative game script — a likely scenario we see on Thursday Night.

San Francisco 49ers
jutpicks
Justin Martin (JutPicks)

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Money Line

The 49ers have won 14 of their last 20 home games.

Point Spread

The Rams have covered the spread in 4 of their last 5 matchups against divisional opponents.

Game Totals

Each of the last 4 games between the 49ers and the Rams has gone Over the expected points total.

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Gambling Problem? Call 1-800-GAMBLER. Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ and present in select states. FanDuel is offering online sports wagering in Kansas under an agreement with Kansas Star Casino, LLC. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, KY, MI, NJ, OH, PA, IL, TN, VA, VT), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), visit www.mdgamblinghelp.org (MD), 1-800-522-4700 (WY), or visit www.1800gambler.net (WV).

DraftKings

$150

Bet $5, Get $150 in Bonus Bets Instantly

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5 on any sports market and get $150 in bonus bets

Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $200 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at sportsbook.draftkings.com.

Caesars Sportsbook

$1,000

$1,000 First Bet on Caesars

Sign up for a new Caesars Sportsbook account and Place your 1st wager of $10 or more

Place your first wager up to $1,000

If the bet losses, earn a a one-time Bonus Bettoken equal to the qualifying wager

21+. New users and first wager only. See Caesars.com/promos for full terms. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER. MA: CALL 1-800-327-5050 NY: Call 877-8-HOPENY or text HOPENY (467369)

bet365

$1,000

Bet $5 and Get $150 in Bonus Bets OR $1,000 Back If Your First Bet Loses

Register for a new bet365 account

Place $5+ and get $150 in bonus bets - no matter if your bet wins or loses

OR $1,000 back in bonus bets if your first bet loses

Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in OH, CO, NJ, VA, IA, KY, LA, AZ, IN. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer. Deposit required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers only. T&Cs, time limits and exclusions apply

Underdog Fantasy

$1,000

First Time Deposit Offer up to $1,000 in Bonus Cash

Sign up for a new account with Underdog Fantasy

Make your first deposit up to $1,000

Get a 100% deposit match, and new users can get up to $1,000 in bonus cash on their first deposit

Must be 21+ to play. Terms & conditions apply

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