Buffalo Bills vs Indianapolis Colts Prediction, Odds and Picks for Sunday, 11/10/24

It terms of situational spots, it doesn’t get much better for the Colts this week as a short underdog at home. The Bills are coming off a recent stretch of games that ran the gamut of outcomes and emotions, including a massive road win over the Jets, a decisive victory in Seattle against the Seahawks and a thrilling win in the final seconds over the Dolphins a week ago, thanks to a 61-yard field goal from Tyler Bass. With Buffalo now holding a massive lead in the AFC East standings, the Bills are set to travel to Indianapolis for a date with the Colts before returning home to face the Chiefs in what will surely be the biggest game in the race for the top seed in the AFC this season. 

Given that the Bills have this massive revenge game against Kansas City on deck and a slew of injuries to navigate on both sides of the ball, including wide receivers Keon Coleman and Amari Cooper, cornerback Christian Bentford and defensive lineman Dawuane Smoot, it would be easy to see why Buffalo could go through the motions in this game. After all, this team is likely going to make the playoffs and should just try to make it to next week’s game healthier than this week. Therefore, while the Colts offense struggled mightily with Joe Flacco under center a week ago, Indianapolis should bounce back and generate a bit more success offensively in this one against a Bills defense that rarely brings pressure and allows opponents to move the ball methodically downfield by design. Jonathan Taylor should also have a very solid game here, as Buffalo has struggled to defend some of the better rushing attacks on its schedule this season. This one should be closer than most expect, so let’s take the home underdog at anything over a field goal.  

Bills vs Colts predictions: Colts +4.5 available at time of publishing. Playable to +4.

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