Arizona Cardinals vs San Francisco 49ers Prediction, Odds and Picks for Sunday, 10/06/24
LLWLL | Last 5 | LWLLW |
| 1-3 | Record | 2-2 |
| 2-2-0 | ATS Record | 2-2-0 |
| 3-1 | O/U Record | 3-1 |
Cardinals vs 49ers Pickswise Expert Predictions
The Arizona Cardinals and San Francisco 49ers will face off in an NFC West rivalry this Sunday at Levi’s Stadium. The Cards enter this one after a disappointing 42-14 home defeat to the Washington Commanders. This defeat marked their second straight home loss, as they failed to score over 14 points for the second straight game. Arizona’s passing game has been unreliable through 4 games, but they’re still recording 153.3 rushing yards per contest (5th in the NFL). It seems like QB Kyler Murray is looking for rookie star WR Marvin Harrison Jr., and if he isn’t open, he has no other options. While Harrison has scored 4 TDs in the last 3 games, Murray must look for alternatives because teams will continue to double-up on MHJ.
The 49ers play at home for the second straight week after they picked up a 30-13 victory over the New England Patriots. Although it was a great win, it was against the lowly Patriots, and I’m not going to say San Francisco has turned things around after they suffered road defeats to the Vikings and Rams in Week 2 and Week 3. The biggest issue for San Francisco is their health because star LB Fred Warner exited the game with an ankle injury in the first half while starting DT Jordan Elliott suffered the same fate. There is no way this defense will be 100% on Sunday, even though head coach Kyle Shanahan said both players are day-to-day entering this week’s practice.
The 49ers have recently dominated this matchup when playing at home, but this line seems high for a divisional rivalry. Additionally, the line opened at +9.5 before moving down to +7.5, and I don’t believe the public is rushing to back a Cardinals team that has scored just 27 points over the last 2 weeks. I said that I was buying low on Arizona in my Commanders vs Cardinals prediction in Week 4, and I’m taking that to another level. Let’s back the Cards again because Kyler Murray is 26-15-2 (62.8%) ATS as an underdog in his career compared to 10-16-0 (38.5%) as a favorite.
Cardinals vs 49ers prediction: Cardinals +7.5 (-110) available at the time of publishing, playable down to +7.
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Luke Lindholm
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Model projections coming soon
The 49ers have covered the spread in 5 of their last 7 games against the Cardinals.
The Cardinals' last 3 road games at the 49ers have gone Over the total.
The 49ers have won 4 of their last 5 games at home against divisional opponents.
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