Arizona Cardinals

Arizona Cardinals vs Carolina Panthers Prediction, Odds and Picks for Today, 12/22/24

Bank of America StadiumFOX
Cardinals
7-7
Cardinals
Today
Panthers
3-11
Panthers

Vote on who will cover the spread!

Carolina Panthers

Cardinals vs Panthers Pickswise Expert Predictions

Arizona Cardinals
NFL
Carolina Panthers
Point Spread Pick
ARZ Cardinals -4.5(-110)ARZ Cardinals @ CAR Panthers

The Cardinals kept their playoff hopes alive as they beat the Patriots 30-17 last Sunday. Kyler Murray was impressive in the win as he completed 23 of his 30 passes for 224 yards but no touchdown passes. That’s because every time the Cardinals got close to the end zone, it became James Conner territory. The veteran back just signed an extension in Arizona and celebrated it by running for 110 yards on just 16 carries. On the other side of the ball, the defense held Drake Maye to just 202 yards through the air and Rhamondre Stevenson to just 69 yards on the ground. It’s been the defense that has been inconsistent at times this season which has become the main reason for Arizona’s struggles, but it was good to see the secondary step up last week. The defense gets a somewhat favorable matchup again in Week 16 against the Panthers.

Carolina was the favorite in a game for the first time since Week 15 of 2022 and it didn’t go well. The Cowboys upset the Panthers 30-14 as the secondary just couldn’t stop CeeDee Lamb through the air or Rico Dowdle on the ground. Early on in the game, it became very apparent that Cooper Rush was looking for Lamb any chance he could and that led to him having 9 catches for 116 yards and a touchdown. That leads me to believe Marvin Harrison Jr. could be in for a big day against this weak Panthers secondary. Plus, Carolina has one of the worst run defenses in football. The Panthers have allowed 173 rushing yards per game which is the worst mark in the league. In fact, they allow 29.3 more rushing yards per game than the team ranked 31st. That Swiss cheese defensive line got carved up by Dowdle last week as he ran for 149 yards on 25 carries. That provides Conner with an excellent matchup on the ground. It’s a short spread so I’m willing to back the Cardinals in Carolina.

Cardinals vs Panthers prediction: Cardinals -4.5 (-110) available at time of publishing. Playable to 5.

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Kevin Davies
Arizona Cardinals
NFL
Carolina Panthers
Game Totals Pick
Over 46.5(-110)ARZ Cardinals @ CAR Panthers

It makes sense that the Panthers allow the most points per game in the league considering they have the worst run defense and a below-average secondary. Carolina has allowed 29.9 points per game which leads me to believe the Cardinals will finish with 24-34 points. I think the Panthers defense is going to have a hard time limiting Harrison Jr. and Trey McBride because of their size and physicality. We saw Lamb carve up the Panthers secondary last week so it could certainly happen again in Week 16 with Harrison Jr. as the main benefactor. Plus, Conner should run wild against this defense.

Only one team has a higher percentage of the Over cashing than the Panthers. 10 of Carolina’s 14 games have surpassed the set total with only the Ravens ahead of them. The combination of low totals because of their offense with a terrible defense has been the perfect recipe for a lot of points. I can see a score around 30-21 in favor of the Cardinals which leads me to take Arizona’s spread combined with the Over.

Cardinals vs Panthers prediction: Over 46.5 (-110) available at time of publishing. Playable to 47.

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Kevin Davies
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Kevin Davies

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MLB handicapper for Pickswise hailing from beautiful Boston, Massachusetts. I’ve been playing baseball since I could walk and betting games since I could (legally) gamble! I love a YRFI & NRFI bet and always on the hunt for a winning parlay.
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Top Trends
Game Totals

The Over is 10-4 in Panthers games this season.

Money Line

The Cardinals have lost 3 times in a row as a road favorite.

Point Spread

The Panthers are 4-1 against the spread in their last 5 games at home.

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