NFL Predictions
Get NFL predictions for every game of the 2025-26 season. Our expert NFL predictions come with detailed analysis, key data and trends so you can see our reasoning for every NFL prediction this week and every week.
NFL Predictions Today
At Pickswise, our expert team has NFL predictions today and throughout the 2025 NFL season. Making profitable NFL betting predictions doesn’t just require hours of research and statistical analysis but also a wealth of NFL betting experience to make sense of these trends and find value in the NFL markets each week. There is up to 16 games each week of the 18 week NFL regular season, making successful NFL betting a difficult and time-consuming task. Our NFL predictions give you an expert’s take on every game, so you can make informed NFL bets all-season long.
There is almost an infinite amount of ways to wager on a game, but the most popular wager amongst NFL bettors is Against the Spread betting, where you’re taking a team to win by more or lose by less than the margin set by the oddsmakers. Aside from the NFL Against the Spread markets, other popular markets include over/under (also known as totals), NFL parlays and NFL prop bets, there is a wager type for every kind of football fan so we provide expert NFL predictions for every NFL betting market.
NFL Score Predictions
NFL score predictions are a great way of determining which markets you think may be right for that particular game. Lots of statistical research and number crunching goes into predicting the score of an NFL team but it can give you an edge before looking at the odds, lines, and bets on offer. Check out our NFL Computer Picks page where our computer looks at historical and up to date NFL stats, plus a whole host of game-specific information to produce NFL score predictions for every game. Combined with the NFL predictions from our experts you’ll get how the stats suggest the scoring will play out and the opinion of handicappers with decades of experience in NFL score predictions.
How Pickswise Makes NFL Predictions
At Pickswise we have a multi-faceted approach to NFL predictions. First, our computer provides thousands of simulations of every NFL game, taking into account all the advanced stats, from third down conversion rate and 4th down aggressiveness to defensive pressure rate and red zone conversion. However, football isn’t played on a spreadsheet, so our expert team brings the analysis and knowledge only years of NFL handicapping experience can provide.
Expert analysis of the vast array of stats and data we have available, with a professional judgement by our experts, is a winning process. We strongly believe both the numbers and the expertise are fundamental to making accurate NFL predictions game after game and season after season, that’s why our NFL predictions are the best in the business.
How to Use Our NFL Predictions
To make the most of our expert NFL predictions, bettors should treat them as a strategic tool for identifying value bets where our expert analysis aligns with statistical trends, injury news, or line movement. One practical approach is to use our expert picks to spot consensus plays, especially on less obvious games where public bias might skew the odds.
For newcomers or those looking to reduce risk, it’s smart to pair our expert NFL predictions with sportsbook promotions. Many top sportsbooks offer bonuses or first bet insurance for new users, which can be used to back our expert selections. This not only boosts your potential returns but also allows you to build a betting strategy and test new betting markets with your bonus bets.
NFL Predictions This Week
While some sites only focus on those marquee matchups each week, the games when the prime time lights are shining, here at Pickswise we cover every game with our NFL predictions this week. Finding those under the radar matchups that won’t attract as much attention can often bear the sweetest fruits. These matchups can often offer great value odds on markets, and our NFL predictions consider this every week. Whether it’s an NFL prop bet or a points line that we think may be good value, we will be on hand to make the most of every game on the NFL schedule. Our NFL predictions is a great place to get the low down on all of the NFL action this week, and how our experts see them shaping up.
Expert NFL Predictions throughout the 2025 NFL season.
When it comes to making NFL predictions, our expert handicappers put in hours of research and analysis before locking in their predictions for every game, all season long. With each game prediction comes detailed reasoning and analysis to make sure our results are among the best in the industry.
Andrew Wilsher, Pickswise Managing Editor
