NFL Parlays

Get our best NFL parlays every week of the 2024-25 season. Our experts combine their best NFL bets to create the best NFL parlay picks this week. You can also find our NFL same game parlays from each game, all season long.

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Sunday's NFL Week 16 parlay
Yesterday
Arizona Cardinals
Carolina Panthers
ARZ Cardinals @ CAR Panthers · Point Spread
ARZ Cardinals -4.5
Our Analysis

The Cardinals kept their playoff hopes alive as they beat the Patriots 30-17 last Sunday. Kyler Murray was impressive in the win as he completed 23 of his 30 passes for 224 yards but no touchdown passes. That’s because every time the Cardinals got close to the end zone, it became James Conner territory. The veteran back just signed an extension in Arizona and celebrated it by running for 110 yards on just 16 carries. On the other side of the ball, the defense held Drake Maye to just 202 yards through the air and Rhamondre Stevenson to just 69 yards on the ground. It’s been the defense that has been inconsistent at times this season which has become the main reason for Arizona’s struggles, but it was good to see the secondary step up last week. The defense gets a somewhat favorable matchup again in Week 16 against the Panthers.

Carolina was the favorite in a game for the first time since Week 15 of 2022 and it didn’t go well. The Cowboys upset the Panthers 30-14 as the secondary just couldn’t stop CeeDee Lamb through the air or Rico Dowdle on the ground. Early on in the game, it became very apparent that Cooper Rush was looking for Lamb any chance he could and that led to him having 9 catches for 116 yards and a touchdown. That leads me to believe Marvin Harrison Jr. could be in for a big day against this weak Panthers secondary. Plus, Carolina has one of the worst run defenses in football. The Panthers have allowed 173 rushing yards per game which is the worst mark in the league. In fact, they allow 29.3 more rushing yards per game than the team ranked 31st. That Swiss cheese defensive line got carved up by Dowdle last week as he ran for 149 yards on 25 carries. That provides Conner with an excellent matchup on the ground. It’s a short spread so I’m willing to back the Cardinals in Carolina.

Cardinals vs Panthers prediction: Cardinals -4.5 (-110) available at time of publishing. Playable to 5.

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Detroit Lions
Chicago Bears
DET Lions @ CHI Bears · Point Spread
DET Lions -6.5
Our Analysis

The Detroit Lions travel to Soldier Field this Sunday to take on the Chicago Bears in the second meeting between these squads. They faced off on Thanksgiving, and although the Lions jumped out to a 16-0 halftime lead, the Bears fought back and had the chance to attempt a game-tying field goal as the clock expired. However, their disgraced head coach, Matt Eberflus, completely mismanaged the clock, and the Bears fell 23-20. He’s since been dismissed, but things haven’t improved for Chicago, as they’re 0-2 since the firing and have been outscored 68-25 against the 49ers and Vikings.

Detroit enters this matchup after suffering their second defeat of the season, 48-42, at the hands of the Buffalo Bills. Josh Allen further solidified himself as the MVP favorite, and Buffalo had a 35-14 3rd-quarter lead before Detroit stormed back and made it a game. Head coach Dan Campbell made a questionable call to go for an onside kick with 11 minutes left in a 10-point game, which ultimately killed the Lions’ momentum. Additionally, they lost RB David Montgomery to a knee injury, and while he’s seeking a second opinion on the injury, it looks like Detroit will likely be without him for this game and the rest of the regular season.

The Lions were 9-1 ATS before failing to cover each of their last 3 games, but they’re still 5-1 against the number on the road and have been elite under Dan Campbell after a loss. Since Week 9 of the 2022-23 season (Campbell’s second season in charge), Detroit is 8-0 following a defeat, winning by an average of 16.3 ppg. They failed to cover against the Bears in the first meeting, but I have to think Chicago has very little motivation to win this game and expect a beatdown by Detroit. 7 of the Lions’ 12 wins this year have come by a TD or more, and I expect them to get another 7+ point victory in Chicago this weekend.

Lions vs Bears prediction: Detroit -6.5 (-110) available at time of publishing. Playable to 7 (-110).

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Minnesota Vikings
Seattle Seahawks
MIN Vikings @ SEA Seahawks · Point Spread
MIN Vikings -3.0
Our Analysis

There is a lot of injury uncertainty around this game, which makes it a bit harder to handicap when diving into how the teams match up with each other. With that being said, it’s hard for me to ignore how poor the Seattle offense looked against Green Bay last Sunday, particularly on the offensive line. Geno Smith has been under duress all season long, and the dam finally broke in last week’s contest, as he was forced to leave the game with an injury. Smith’s status is uncertain for this game, and as of Thursday morning, the betting market is anticipating that Smith will not play this week, even though he did practice in limited capacity on Wednesday. The offensive line situation is one that could get even worse for the Seahawks, as starting center Olu Oluwatimi could end up missing this game, meaning that rookie Jalen Sundell would need to step up in his place. Whether Smith gets the start or Sam Howell ends up being needed off the bench, it could be a long day for this Seattle passing offense.

As for the Vikings, Minnesota hasn’t exactly faced a murderers’ row of opponents in recent weeks. However, Minnesota’s coaching staff is one of the best in the league for a reason, as Kevin O’Connell and company continue to get the most out of Sam Darnold and this offense. Aaron Jones is coming off back-to-back rock-solid performances, and he’ll be going up against a Seahawks run defense that struggled mightily to stop Josh Jacobs and the Packers a week ago. Justin Jefferson has 3 touchdowns over the last 2 weeks, and he’ll instantly create matchup problems for this Seattle secondary. I don’t expect a ton of points from either side in this one, but my lean would still be on the road favorites to cover the short number here.

Vikings vs Seahawks prediction: Vikings -3 (-105) available at time of publishing. Playable at that number.

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Sunday's NFL Week 16 mega parlay
Yesterday
Tennessee Titans
Indianapolis Colts
TEN Titans @ IND Colts · Money Line
TEN Titans Win
Our Analysis

Last week was a nightmare for Will Levis. The Titans quarterback completed just 8 of his 12 passes for 89 yards with 3 interceptions. He kept finding open guys, but they weren’t always on his team. He was benched for Mason Rudolph after his 3rd pick and Rudolph looked extremely sharp in the second half. He finished 21/26 for 209 yards and 2 touchdowns, which brought the Titans back into the game. With that said, Levis had caused too much damage to complete the comeback. There were questions after the loss about which quarterback would start in Week 16 and Brian Callahan didn’t take long to announce that it would be Rudolph. Right now, the Titans appear to have a better chance to win with the veteran quarterback under center. With Rudolph back, Tony Pollard in the backfield, and Calvin Ridley as the main target, the Titans have potential.

The bye week appeared to do more damage than repair for the Colts. Indy went into the bye fresh off a 25-24 victory over the Patriots and came out of the bye looking flat. They lost 31-13 to the Broncos in Denver and Anthony Richardson looked terrible. He completed just 17 of his 38 passes to go with 2 interceptions. His accuracy has always been a topic for debate and it hasn’t appeared to improve yet. I’m expecting Richardson to have a hard time against the Titans’ defense since Tennessee’s secondary is elite. The secondary is allowing the 3rd-fewest passing yards per game this season. I’m taking a shot on the Titans with Rudolph back under center.

Los Angeles Rams
New York Jets
LA Rams @ NY Jets · Alternate Point Spread
LA Rams -6.5
Our Analysis

Both the Rams and Jets won in Week 15, but the victories couldn’t have been more different. The Rams beat the 49ers 12-6 in what might be the most boring Thursday Night Football game of the year and the Jets made a second-half comeback against Mac Jones and the Jaguars. But make no mistake – these teams are headed in opposite directions. The Rams are 8-6 and have proven to have one of the most dangerous offenses in the game. Between Kyren Williams, Puka Nacua and Cooper Kupp, Matthew Stafford has plenty of offensive weapons to choose from. It’s hard to imagine a defense that just allowed 25 points to Mac Jones and the Jags will be able to contain Stafford and the best receiving duo in football.

New York’s win snapped a 4-game losing streak and earned their 4th victory of the season. The entire year has been a disappointment for the Jets and there seems to be a lot of rift between Aaron Rodgers and Garrett Wilson. Maybe that’s because Davante Adams recorded 9 catches for 198 yards and 2 touchdowns and Wilson hauled in just 3 catches for 56 yards. Adams has completely stolen Rodgers’ attention from Wilson. Plus, Breece Hall still doesn’t look 100% healthy. I was baffled to see the spread as just a field goal, so I’m taking an alternate spread to get the best value for the Rams.

Tampa Bay Buccaneers
Dallas Cowboys
TB Buccaneers @ DAL Cowboys · Alternate Point Spread
TB Buccaneers -6.5
Our Analysis

Sunday Night Football will feature Baker Mayfield against Cooper Rush. If you like points, this game should be perfect for you. The Buccaneers have been one of the biggest surprises of the season as they are 8-6 and right in the thick of the playoff hunt. It’s even more impressive considering Mayfield was without Mike Evans and Chris Godwin for several weeks and had to make do with Cade Otton being the #1 option. But now that Evans is back, the Bucs’ offense has become extremely balanced. Otton has earned Mayfield’s trust, Rachaad White remains a valuable receiving back and Bucky Irving has blossomed into a true RB1 in the last few weeks. That led them to score 40 points against an elite Chargers defense last week. I love this matchup for Mayfield on Sunday night.

It feels weird to say, but the Cowboys actually upset the Panthers last week. Carolina was the favorite in a game for the first time since Week 15 of the 2022 season, and in classic Panther fashion, they blew it. Bryce Young was terrorized in the pocket as he threw 2 interceptions and was sacked 6 times. Plus, the offense lost 2 fumbles. On offense, the Cowboys looked much more fluid. Rush was targeting CeeDee Lamb whenever he could and Rico Dowdle went crazy on the ground for 149 rushing yards. But remember — the Panthers’ defense is one of the worst units in football. I’m expecting a much better defensive performance from the Bucs as they win this primetime game by at least a touchdown.

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NFL Video

What Is An NFL Parlay

An NFL parlay is a type of bet where you combine multiple selections into a single wager. For an NFL parlay to win, all of the selections or bets need to win. While the difficulty of winning an NFL parlay increases with each selection you add, the odds can also greatly increase. To calculate the odds of a parlay you multiply the odds of the individual selections so the more selections, the bigger the parlay odds. You can also make use of our Parlay Calculator to take care of all of the math for you. For more on Parlays be sure to check out our Parlay betting guide.


Our experts will highlight the best NFL Picks today to combine into an NFL Parlay, offering you even more variation into how you want to wager on this week’s NFL action.

Free Picks and Parlays NFL 

Here at Pickswise, we have free NFL picks and parlays every week of the NFL season. Our free NFL parlays include both traditional multi-game parlays which include our best parlay picks from the most popular markets including money line, spreads, and totals, as well as our NFL Same Game parlays. Each of our free NFL parlays will come with a full analysis for each leg, as well as the best odds available from all of the top online sportsbooks. Check back every week including for those primetime parlay picks on Mondays, Thursdays, and Sunday Night Football.

NFL Parlay Strategies & Tips

Parlay Bets despite their popularity can be one of the most difficult and lucrative bets, with increased difficulty with each selection you add. It’s important to remember that over the course of the NFL season even experts will very likely lose more parlays than they win. However, the nature of parlay betting means the wins you do get turns more profit.

In the 2023-24 NFL season our expert handicappers landed 38.5 units of profit from parlays, so you need to look no further for a trusted source of NFL parlay picks.


Here are three quick tips to better your chances of winning long-term with your NFL Parlays

  1. Stick to 2, 3, or 4 team parlays – Any more than this will often not be profitable long term despite the increased parlay odds. 
  2. Shop around for odds – Not all online sportsbooks offer the same odds, and while there is often only a marginal difference if you can wager three picks at -105 each instead of -120, your payout would be $744.21 instead of $616.20 to a $100 stake.
  3. Manage your bankroll –  Being disciplined with your bankroll is key long term as not all parlays will win, particularly in the NFL, but if you keep your stake consistent, at odds of around 6/1, you only need to win 1 in 7 parlays to break even, any better than that is profit.

How to bet on NFL Picks and Parlays

Betting on NFL picks and parlays is a quick and simple process with any online sportsbook. To create a parlay, you simply have to add multiple selections to your bet slip and click the parlay option before placing your wager.

Due to the popularity of NFL betting and also NFL parlays, sportsbooks pay a considerable amount of attention to these markets, and in shopping around you can find great variations in odds, spread lines, and often price boosts or bonuses such as Parlay insurance whereby you get your stake as a bonus bet if only one leg lets you down. Shopping around for these advantages is key to having long-term success with NFL parlays.

Unsure where is best to place your NFL parlay bets? Head over to our
online sportsbook promotions page where we break down all the information and latest promo codes you’ll need to know to unlock bonuses and make your NFL betting easier.

What is an NFL Teaser Bet?

One of the ways to avoid the frustration of losing an against-the-spread bet by a point or two is with teaser NFL picks. For example, in a 2-team teaser, you get 6 points placed in your direction (-7 spread becomes -1) for both games. The caveat is that both teams must cover for your ticket to be graded a winner and the odds are similar to a single-game bet. Conversely in a parlay, you still wager on two teams but with the original spread and with better payout odds (usually 3:1). Teasers and parlays can be played with 2,3,4,5 teams or more.

What Is A Same Game Parlay 

A Same Game Parlay is just like a regular parlay wager, except all selections come from prop bets within one specific game. The obvious positive of a Same Game Parlay is that by combining multiple selections you can go for an even bigger win with the odds increasing with each selection.

Bettors will often use Same Game Parlays to wager on correlated props, and if you get it right the payouts can be huge. Take, for example, a team facing a poor pass defense with an elite QB, in that spot, you might take the QB to hit over their passing yards total and you can also parlay that with their favorite wide receiver to score anytime and the team to win.

How Do I Bet On A Same Game Parlay

With the Same Game Parlay’s increasing popularity, the majority of leading online sportsbooks now offer them across a number of sports, including the NFL. Some refer to them as One Game Parlays and Single Game Parlays, which are different in name, but the same in concept.

To bet on a same game parlay simply head to your preferred online Sportsbook, or where you can get the best odds for your picks. Unsure of the best online sportsbook for the NFL? Check out our guide to the best NFL betting sites today.

To bet a Same Game Parlay you must first click on the game you want to place a bet on, and then add each selection to your betslip. The Same Game Parlay odds update with each pick. Once you have added all of your selections, enter the amount you wish to wager and hit ‘place bet’. And that’s it, you’re on!

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FanDuel, BetMGM, DraftKings and Caesars and unlock welcome bonuses for the 2024 NFL season.

NFL Parlays: Betting small to try to win big

Bet small, win big. That’s the aim of every NFL parlay and our team of experts spend hours each week crafting what they believe to be the perfect parlay to deliver a nice payout. Our handicappers are among the best in the business at doing just that, with each leg the product of intensive analysis from numerous members of the Pickswise capping team. Our record speaks for itself when it comes to NFL parlay expertise, throughout the 2023 season our NFL parlays had scored 38.5 units in profit.

Andrew Wilsher, Pickswise Managing Editor

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NFL Parlays FAQs

You cannot parlay NFL Win Totals bets as the outcomes of the events are closely correlated. If you were to bet the Overs on the Saints, but the Unders on the Buccaneers for example, and the Saints beat the Bucs twice in a season, both outcomes are likely to increase their chances of winning.

A parlay bet in the NFL is when you combine multiple straight bets into one single bet. Every pick within the parlay must win for the ticket to cash, but the odds also increase in line with the risk of adding more picks, making them fruitful if they hit. 

You can parlay certain NFL futures before and during the season, but it will vary from sportsbook to sportsbook. One example would be division winners, you can try to hit a big parlay and predict all 8 division winners in a season. Some sportsbooks will also allow you to parlay Player Awards such as Offensive and Defensive Rookie of The Year.

Parlays can be worth it, but it’s also worth keeping in mind that the more picks you have in a parlay the harder it will be to win. However, with the odds of each individual pick multiplying to give you the parlay odds, it allows you to bet smaller units to try and win bigger returns than a straight wager.

The disadvantage of a parlay is its difficulty to win. While the odds are often great, adding each pick will also increase the risk of the bet winning as every selection has to win for the ticket to cash, a single losing leg with 5 winning ones still returns $0.

Parlays are popular because they offer the opportunity of betting small and win big. For example, if you were to parlay 6 teams against the spread, you should expect odds of around +4500 meaning a $50 bet would return $2,300.

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