NFL Best Bets

Get our experts’ best NFL bets every week of the 2024/25 season. Our experts analyze their NFL picks and predictions across a whole host of markets to find you their best NFL Bets every week, right here.

Pickswise’s NFL Best Bets went 66-43 for +45 Units of profit throughout the 2023/24 NFL Season.

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Los Angeles Chargers
Sat Dec 28
New England Patriots
Point Spread PickBest Bet
LA Chargers -4.0(-110)LA Chargers @ NE Patriots

The weather will be good in Foxborough this weekend, and that’s obviously good news for the visiting Los Angeles Chargers (even if it will still be a bit cold by their LA standards). It’s safe to say that they have a great chance of clinching a playoff berth when they visit the lowly New England Patriots on Saturday afternoon. Head coach Jim Harbaugh’s crew is 9-6 and currently occupies the second wild-card spot in the AFC. Although the Bolts got blown out by the Buccaneers in Week 15, that is clearly an aberration as opposed to the rule. Los Angeles bounced back with a 34-27 victory over Denver this past Thursday and has won 6 of its last 9 contests. Its other 2 losses during this stretch are 1-possession setbacks against Baltimore and Kansas City.

Meanwhile, New England is 3-12 and has lost 5 in a row. 8 of its last 11 setbacks have come by margins larger than Saturday’s 4-point spread. Rookie QB Drake Maye has been decent, but a once-promising defense has taken a sizable step back of late. The Patriots have allowed at least 24 points in 5 consecutive contests, including 30 or more twice during this stretch. They were without 2 starters in the secondary (Jabrill Peppers and Marcus Jones) during last week’s loss at Buffalo and that could be the case again when the Chargers come to town. Facing a woeful opponent and playing on extra rest, Los Angeles should be expected to win and cover this weekend.

Chargers vs Patriots prediction: Chargers -4 (-110) available at time of publishing. Playable to -5.5.

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Ricky Dimon
Tennessee Titans
Sun Dec 29
Jacksonville Jaguars
Point Spread PickBest Bet
TEN Titans +1.5(-110)TEN Titans @ JAX Jaguars

We’ve got AFC South action on our hands here as the Tennessee Titans make the trip to Florida to take on the Jacksonville Jaguars. There’s no sugarcoating it – both of these teams have been dreadful this season. They are both 3-12 and have been blown out multiple times this season. However, I’m amazed to see that Tennessee is a slight underdog in this game and like their chances of pulling the small upset. For starters, Jacksonville has lost each of its last 2 games to the Jets and Raiders – 2 equally poor franchises. They allowed both Aaron Rodgers and Aidan O’Connell to tear through them and have given up the most passing yards (4,148) and most passing yards per attempt (8.2) in the NFL. They’ve also given up the 4th-most passing touchdowns while making the 3rd-fewest interceptions. The Titans offense was unable to capitalize on that 3 weeks ago, as the Jaguars beat them 10-6 in Tennessee, but it’s worth noting that Will Levis was under center in that game and the Titans have shown vast improvement with Mason Rudolph under center.

Tennessee has put up 27 and 30 points in its last 2 games, with Rudolph posting 4 touchdown passes in that period. Calvin Ridley has seen an uptick in production while tight end Chigoziem Okonkwo has really started to take off. The Titans’ defense continues to plague them, having allowed the 2nd-most points in the NFL, but it’s unlikely the Jags will be able to take advantage. Jacksonville managed just 10 points against them last time and have mustered 14 points or fewer in 4 of their last 6 games. It could be a rough watch, but the Titans should prevail in this one, but it’s worth taking the extra point as insurance in case it really does come down to the wire.

Titans vs Jaguars prediction: Titans +1.5 (-110) available at time of publishing. Playable to -1.

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Andrew Wilsher Managing Editor of Pickswise
Andrew Wilsher
Detroit Lions
Mon Dec 30
San Francisco 49ers
Point Spread PickBest Bet
DET Lions -3.5(-115)DET Lions @ SF 49ers

Before the season started, NFL schedule-makers must’ve been salivating at this matchup, a rematch of the NFC Championship game right before the playoffs. Many might have predicted that this would be a battle for the #1 seed right before January, and a moment for the Lions to get their revenge. Now, the game looks and feels wildly different, although oddsmakers are still positioning themselves with caution, and with respect for the downtrodden Niners. If any one week served as a microcosm for San Francisco’s season, it was Week 16. San Francisco flew to Miami to face a struggling Dolphins squad last Sunday, an outfit that has little chance of even making the postseason. It was a tight contest throughout, but as we’ve gotten used to seeing from the Niners this season, they flailed in the second half. They also only gained 81 total yards on the ground, a consequence of a very injured backfield and offensive line. On Monday, it was announced that All-Pro left tackle Trent Williams will miss the final 2 games of the season, further adding to the slew of injuries across San Francisco’s roster. They’ve only covered the spread once in their past 7 contests, and they’ve been eliminated from the playoffs.

The Lions, meanwhile, returned to form. After a loss in Week 15 where they allowed the Bills to score 48 points, the Bears were the perfect mince-meat for the hungry Lions. It showed on Sunday. Chicago eventually punched back, but as usual it was too little, too late. Detroit gained 475 yards and had the hapless Bears chasing them for the whole contest. Another big win for the Lions and 2 games remain before they can secure the NFC’s #1 seed. The only reason why we’d consider the 49ers is that Detroit has a look-ahead matchup next Sunday that could decide the NFC North. If the Vikings end up losing on Sunday (4:25 pm ET) to the Packers, that would place Detroit a full game ahead of Minnesota, so the Lions would have a chance to clinch the #1 seed and NFC North with a win at San Francisco. Either way, a Dan Campbell led-roster will undoubtedly come to play, with vengeance on their minds. And, based on 16 weeks of evidence, we simply don’t feel that San Francisco has the manpower or juice to hold them back.

Lions vs 49ers prediction: Lions -3.5 (-115) available at time of publishing. Playable to 4.5.

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Chris R. Farley
NFL Best Bets
54.3%
Win %
51Wins
43Losses
1Pushes
Percentage only includes Wins and Losses

NFL Video

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, and we bring you free NFL best bets across the whole season and post-season.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers, post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details just that, our expert NFL Best Bets on this week’s games.

How Did Pickswise’s NFL Best Bets Perform Last Season?

The expert NFL handicappers at Pickswise saw great success throughout the 2023/24 NFL season and their best bets were no different. We post multiple best bets each week of the season, all accompanied by analysis, data and trends that are all fact-checked by our editors. Check out our 2023/24 NFL Best Bets records below;

2023-24 NFL Best Bets Record
WinLossProfit/Loss
6643+45 Units

NFL Best Bets Today

The NFL action comes thick and fast during the season and we cover all of it. The NFL Best Bets page should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best Bets For NFL This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different. You can often find great value early in the week and our experts will take an early look ahead every week, and aim to get our best bets for NFL this week posted on-site as soon as possible, to try to lock in those best lines and odds. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over time.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


+45 Units from 2023/24 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2023 season, our team of expert NFL handicappers finished +45 units in profit on our best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets saw a return of +45 units across the 2023/24 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.

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