TNF NFL Betting Guide: 49ers vs Seahawks picks, expert predictions, odds & best bets

Seattle Seahawks quarterback Geno Smith (7) passes against the San Francisco 49ers during the third quarter at Lumen Field.
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Andrew Wilsher

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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.
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NFL Week 6 has arrived and kicks off with a huge Thursday Night Football showdown between the San Francisco 49ers and Seattle Seahawks. Both teams suffered brutal losses last Sunday, as the 49ers blew a double-digit lead in the 4th quarter to fall to the Arizona Cardinals, while the Seahawks fell 29-20 to the New York Giants. As things stand, Seattle currently sits top of the division on 3-2 but San Francisco, which has surprisingly struggled through the first 5 weeks, can knock them off that spot if they get the win. Which team will stand tall in the NFC West at the end of the night?

49ers vs Seahawks kicks off at 8:15 pm ET live on Amazon Prime Video, and here at Pickswise, we have everything you need to bet better on this Thursday Night Football matchup, including NFL picks on the side and total, expert NFL player prop bets from props betting experts Prop Holliday and JutPicks, and even a 49ers vs Seahawks Same Game Parlay! Let’s get into our 49ers vs Seahawks picks and predictions for TNF.

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NFL TNF Picks

49ers vs Seahawks best player prop bets

San Francisco 49ers vs Seattle Seahawks Same Game Parlay

If you’re looking to bet on our 49ers vs Seahawks Same Game Parlay picks then we recommend using Fanatics Sportsbook, where you’ll find the best odds available and right now new users can click here to sign up and earn up to $1,000 in bonus bets!

NFL Week 6 Predictions

Find out our expert best bets and predictions for EVERY NFL Week 6 matchup below:

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