Andrew Ortenberg
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Welcome to the Pickswise NFL Week 2 betting guide — our experts have done the research so you have everything you need to beat your book below! The 2021 NFL season will have its second full slate on Sunday, and this is your one-stop shop for all the info you need to inform your wagering.
NFL Week 2 picks
Pickswise Playbook
Make sure you check out Pickswise Playbook, our brand new weekly NFL betting show with Chris Rose, Ross Tucker and Jared Smith as they look to make your next bet better! Out every Thursday
Week 2 betting articles
- Week 2 survivor pool picks
- Week 2 mega parlay (+1516 odds!)
- This week’s hottest betting trends
- Week 2 millionaire parlay
- Jared Smith’s NFL Week 2 best bets
- Man vs Machine: Pickswise expert vs the computer model Week 2
- Prop Bet Guy’s best prop bet for Sunday Night Football
- Best NFL underdog plays for Week 2
- Week 2 anytime touchdown scorer prop bets
Week 2 big game same game parlays
We have same game parlays for every single NFL game, which you can find in our NFL news tab, but here are a select few from the biggest games of Week 2:
- Raiders vs Steelers same game parlay (+987 odds!)
- 49ers vs Eagles same game parlay (+827 odds!)
- Bills vs Dolphins same game parlay (+2523 odds!)
- Cowboys vs Chargers same game parlay (+960 odds!)
- Vikings vs Cardinals same game parlay (+1350 odds!)
Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.
