Andrew Ortenberg
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Welcome to the Pickswise NFL Week 1 betting guide — our experts have done the research so you have everything you need to beat your book below! The 2021 NFL season will have its first full slate on Sunday, and this is your one-stop shop for all the info you need to inform your wagering.
NFL Week 1 picks
Pickswise Playbook
Make sure you check out Pickswise Playbook, our brand new weekly NFL betting show with Chris Rose, Ross Tucker and Jared Smith as they look to make your next bet better! Out every Thursday
Week 1 betting articles
- Week 1 survivor pool picks
- Week 1 mega parlay (+2179 odds!)
- This week’s hottest betting trends
- Week 1 millionaire parlay
- Jared Smith’s NFL Week 1 best bets
- Super Bowl LVI picks expert roundtable
- Behind enemy lines: Oddsmakers’ perspective on NFL betting
- Best underdog plays for Week 1
Week 1 big game same game parlays
We have same game parlays for every single NFL game, which you can find in our NFL news tab, but here are a select few from the biggest games of Week 1:
- Steelers vs Bills same game parlay (+704 odds!)
- Browns vs Chiefs same game parlay (+1307 odds!)
- Packers vs Saints same game parlay (+1574 odds!)
- Seahawks vs Colts same game parlay (+1004 odds!)
- Chicago Bears vs Los Angeles Rams same game parlay (+730 odds!)
Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.
