Our NFL expert's best player prop bet for San Francisco 49ers vs Buffalo Bills on Sunday Night Football

Khalil Shakir of the Buffalo Bills
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Prop Holliday - Bobby Stanley

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The Sunday Night Football gems keep on coming with the Buffalo Bills off a bye week hosting the San Francisco 49ers. The Bills are 5-1 against the spread over their last 6 games while the 49ers are 2-4 ATS in that same span. For San Francisco, it’s clear the window is closing on their Super Bowl run and they’re trying to stay afloat in the NFC West. Nick Bosa and Trent Williams are currently listed as out for Sunday night’s game, and it’s unclear if Brock Purdy will play. For Buffalo, second year tight end Dalton Kincaid is out, but rookie WR Keon Coleman is questionable and trending in the right direction for this contest.

Khalil Shakir (BUF) over 54.5 receiving yards (-115)

Line available on DraftKings Sportsbook at the time of publishing.

Heading into this game, we already know that Kincaid is out for a second straight week and Khalil Shakir should continue his success against the 49ers. Since Week 7 he’s hit this number in 4/5 games and over the last 2 he’s seen a season high 70%+ snap share. The matchup is an advantageous one for Shakir; the 49ers will likely be without DE Nick Bosa and this greatly limits their pass rush. According to PFF, Shakir has a 29.9% target rate on non-pressured drop backs this season, which ranks 18th out of 165 qualified WR this season. Like most of my wagers this season, this is a 1 unit play for me.

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