Opening NFL Week 6 betting lines, odds and spreads: Early betting takeaways for this week's games

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Caleb Wilfinger

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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
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Week 5 of the NFL season saw another crop of upsets in the early window, before the NFC East dominated the 4pm slate. To cap off Sunday’s action, the Ravens knocked off the Bengals on a Justin Tucker field goal as time expired, before the Chiefs edged the Raiders on Monday night. Now it’s time to turn our attention to Week 6.

This slate is another compelling one, with plenty of intriguing matchups. The opening lines were released at most sportsbooks on Sunday night, so let’s take a look at these openers and give our first impressions.

NFL Week 6 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing. 

  • Washington Commanders +1 (-110) vs Chicago Bears – Thursday October 13
  • New York Jets +7.5 (-110) vs Green Bay Packers – Sunday, October 16
  • New England Patriots +3 (-110) vs Cleveland Browns – Sunday, October 16
  • San Francisco 49ers -5.5 (-110) vs Atlanta Falcons – Sunday, October 16
  • Minnesota Vikings -3 (-110) vs Miami Dolphins – Sunday, October 16
  • Baltimore Ravens -5.5 (-110) vs New York Giants – Sunday, October 16
  • Cincinnati Bengals -1.5 (-110) vs New Orleans Saints – Sunday, October 16
  • Tampa Bay Buccaneers -8.5 (-110) vs Pittsburgh Steelers – Sunday, October 16
  • Jacksonville Jaguars +2 (-110) vs Indianapolis Colts – Sunday, October 16
  • Buffalo Bills -1.5 (-110) vs Kansas City Chiefs – Sunday, October 16
  • Arizona Cardinals -3 (-110) vs Seattle Seahawks – Sunday, October 16
  • Carolina Panthers +11 (-110) vs Los Angeles Rams – Sunday, October 16
  • Dallas Cowboys +5.5 (-110) vs Philadelphia Eagles – Sunday, October 16
  • Denver Broncos +5.5 (-110) vs Los Angeles Chargers – Monday, October 17

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Best early bets for NFL Week 6

Seattle Seahawks +3 (-115) over Arizona Cardinals

This line feels mispriced to me, and a lot of that might have to do with the lack of respect in the market for Seattle. This offense is legit. Even against a good Saints defense last week, the Seahawks were efficient and generated a number of explosive plays in the loss. The Seahawks have been extremely successful on early downs this season, thanks in large part to the excellent play of Geno Smith at quarterback. Furthermore, Seattle is one of the better 3rd-down teams in the league as well. This is a good, well-rounded offense and we have 5 weeks of data to support that.

On the other side, Kyler Murray has moments of brilliance, but his inconsistency is indicative of the Cardinals’ performance to this point. Back the Seahawks as home dogs to a divisional foe in this spot.

Read our full Cardinals vs Seahawks predictions

New York Giants +5.5 (-110) over Baltimore Ravens

The New York Giants have been one of the pleasant surprises in the NFL this season, and that momentum should continue this week. Brian Daboll has clearly impacted the locker room in a positive manner and it’s rubbed off on Daniel Jones and the rest of the team. Now the Giants will return home to host a Ravens team that just picked up a massive AFC North win on Sunday night.

This isn’t a perfect spot for New York, seeing as the Giants will be returning from a huge win in London. However, I still think New York can keep this one close against Baltimore, who has had trouble pulling away from teams this season. I’d play this down to 4.

Dallas Cowboys +5.5 (-110) over Philadelphia Eagles

The Eagles have been one of the league’s best teams to this point, as they remain unbeaten heading into this NFC East matchup. However, Philadelphia’s success has come against one of the worst defensive schedules in the league. Through their first 5 games, the only quality defense the Eagles faced was the Jaguars, a game in which they trailed 14-0 early on. In steps a Cowboys defense that has been one of the better units in football to this point. Dallas is 6th in rushing success rate, which will make things difficult on Jalen Hurts and Philadelphia’s rushing attack. Even with Cooper Rush at quarterback, this line is still too high and arguably a bit disrespectful. I’d back Dallas down to +4 in this one.

Keep an eye out for our NFL Best Bets for Week 6 — we’re 19-8 this season

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