NFL Week 16 mega parlay (+1515 odds): Let's make it three out of six after winners in Weeks 11 & 13

Washington Football Team wide receiver Terry McLaurin (17) waves to the Dallas Cowboys fans during the second half at AT&T Stadium.
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Andrew Ortenberg

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I'm an NFL handicapper here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up. For Andrew Ortenberg media enquiries, please email contact@pickswise.com.
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The 2021 NFL season has been thrilling, and we have another great slate coming up for Week 16. Why not celebrate the holidays by going for a big payday? That’s right; we’re back with another mega parlay, NFL edition. Doing one each week of the season. I have had a ton of success with these mega parlays, and even hit one at 74/1 in Week 13 last year.

I also just hit it for Week 11 at +1762, and then again for Week 13 at +1255. We came up one last-second field goal short of cashing the Thanksgiving one at 17/1, as well. Why not do it once more and make it three out of six weeks? We’re going big and bold again, so let’s not waste any more time. But before we dive in, don’t forget to check out our picks for the side and total on every NFL game.

Detroit Lions ML (+240)

Washington Football Team ML (+375)

Parlay odds: +1515

Let’s break down each of the two legs one by one.

Detroit Lions ML (+240) over Atlanta Falcons

I’m sorry, but I don’t care who is starting at quarterback for the Lions. The Falcons shouldn’t be this large of a favorite against anybody. I mean we’re talking about an Atlanta team that has a point differential of -126. That’s actually worse than the Lions’ point differential this season! Tim Boyle didn’t fare well at all in his first start this season, but that was in a really tough spot. Boyle was thrust into the starting role at the last minute on the road in Cleveland in a game that had harsh weather conditions.

Now he’s getting to face a much softer Falcons defense in a dome, and he won’t have the nerves of it being his first start anymore. Boyle should look a lot more comfortable and Detroit has quietly been doing some nice things schematically on offense lately. The Falcons can’t block anybody, and they’re just 2-4 in their last six games. The two wins in that span came against floundering Jaguars and Panthers teams.

Be sure to check out our full game preview

Washington Football Team ML (+375) over Dallas Cowboys

To wrap up this mega parlay and hopefully bring us home, we have Washington on Sunday Night Football. Nobody is really talking about it because they’ve been winning games, but the Cowboys’ offense has really struggled lately. Dak Prescott hasn’t looked like himself, and even in their win over the Giants last week he averaged just 5.9 yards per attempt. Dallas only won that game because Mike Glennon was on the other side.

When these teams first played a couple of weeks ago, Prescott averaged a mere 5.4 yards per attempt and threw two interceptions. I also don’t think Dallas’ defense is quite as good as they’ve seemed the past few weeks against a really easy schedule. Remember when they gave up 36 to a struggling Raiders offense just a few weeks ago? Head coach Ron Rivera’s squad is a resilient bunch and it certainly isn’t going down without a fight.

Be sure to check out our full game preview

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