NFL betting guide: Expert Week 12 NFL predictions, picks, odds & best bets

Welcome to the Pickswise NFL Week 12 betting guide! On the heels of an exciting first 11 weeks, we’ve got a massive slate of football in store for us, headlined by a trio of marquee matchups in Cardinals vs Seahawks, 49ers vs Packers and Eagles vs Rams

What’s in store for Sunday? Well, our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the Week 12 slate of the NFL regular season. 

NFL Week 12 picks 

• NFL picks against the spread and total for EVERY Week 12 game 
• NFL best bets  
• NFL parlays 

NFL Week 12 expert betting parlay picks and predictions 

• NFL expert best bets
• NFL Sunday mega parlay (+990 odds!)
• NFL SNF Same Game Parlay

NFL Week 12 prop bets 

• NFL Week 12 SNF prop bets
• NFL Week 12 prop bets
• Week 12 touchdown scorer best bets 

NFL Week 12 big-game predictions 

• Lions vs Colts predictions 
• Vikings vs Bears predictions
• Bucs vs Giants predictions
• Cardinals vs Seahawks predictions
• 49ers vs Packers predictions
• Eagles vs Rams predictions
• Ravens vs Chargers predictions