NFL betting guide: Expert Week 10 NFL predictions, picks, odds & best bets

Welcome to the Pickswise NFL Week 10 betting guide! On the heels of an exciting first 9 weeks, we’ve got another terrific weekend of football in store for us, headlined by a couple of marquee matchups in Lions vs Texans and Steelers vs Commanders.  

What’s in store for Sunday? Well, our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the Week 10 slate of the NFL regular season. 

NFL Week 10 picks 

• NFL picks against the spread and total for EVERY Week 10 game 
• NFL best bets  
• NFL parlays 

NFL Week 10 expert betting picks and predictions 

• NFL Sunday mega parlay (+1029 odds!)
• NFL SNF Same Game Parlay

NFL Week 10 prop bets 

• NFL Week 10 SNF prop bets
• NFL Week 10 prop bets
• Week 10 touchdown scorer best bets 

NFL Week 10 big-game predictions 

• 49ers vs Buccaneers predictions 
• Bills vs Colts predictions
• Steelers vs Commanders predictions
• Jets vs Cardinals predictions
• Eagles vs Cowboys predictions
• Broncos vs Chiefs predictions
• Lions vs Texans predictions