Welcome to the Pickswise NFL Week 10 betting guide! The week got off to a thoroughly unspectacular start with a boring Thursday Night Football contest between the Carolina Panthers and Atlanta Falcons, but that is nothing new for TNF this season. That should not be a sign of things to come for the rest of the Week 10 slate.
Sunday should begin with a bang, as the Tampa Bay Buccaneers need a second straight victory in the worst way but have to go up against the NFC West-leading Seattle Seahawks. That showdown will be the first NFL game played in Germany and gives the Sunday slate an early start at 9:30am ET. Meanwhile, Buffalo Bills are hosting the Minnesota Vikings and Dallas Cowboys head coach Mike McCarthy returns to Lambeau Field for a date with the Green Bay Packers.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday – and for Commanders vs Eagles on Monday Night Football. Don’t forget to check out our NFL game previews, which now include prop picks, projections, trends and Same Game Parlays.
Our handicappers engineered a stellar first half of the 2022 season, as we are 34-20 on our best bets. Let’s keep the momentum going!
NFL Week 10 picks
- NFL picks against the spread and total for EVERY Week 10 game
- NFL best bets
- NFL parlays
NFL Week 10 expert betting picks and predictions
- Jared Smith’s Week 10 best bets
- NFL Week 10 mega parlay (+960 odds!)
- Our NFL experts’ best bets
- Millionaire maker 12-team parlay
- Week 10 best bets on Prophet Exchange
NFL Week 10 prop bets
- Sunday NFL player props – from Prop Holliday, who is on a 7-4 run
- Week 10 touchdown scorer picks including exclusive DraftKings +100 bonus!
- SNF Chargers vs 49ers Same Game Parlay
- SNF Chargers vs 49ers TD scorer picks
- ThriveFantasy Week 10 player props
NFL Week 10 Promo Codes
- BetMGM Promo Code: Bet $10 Win $200 if either NFL Team scores a TD
- DraftKings Promo Code: Bet $5+ On Any NFL Pre-Game ML, Get $200 If Your Bet Wins
- FanDuel Promo Code: No Sweat First Bet up to $1,000 on NFL
- Caesars Promo Code: Up To $1,250 Back On Your First Bet + 1000 Tier Credits + 1000 Reward Credits®
- PointsBet Promo Code: Get 4x $200 Second-Chance Bets For The NFL
Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 10, including sportsbooks live in your state.
NFL Week 10 big-game predictions
- Seahawks vs Buccaneers predictions
- Vikings vs Bills predictions
- Jaguars vs Chiefs predictions
- Browns vs Dolphins predictions
- Broncos vs Titans predictions
- Cowboys vs Packers predictions
- Cardinals vs Rams predictions
- Chargers vs 49ers predictions
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