Phil Agius
Show Bio
Welcome to the Pickswise NFL Week 1 betting guide. The nation’s favorite sport is back in full force on Sunday with 28 teams playing for the first time this season — and there are some great revenge games on a sizzling slate with the Browns facing new Panthers QB Baker Mayfield and Russell Wilson returning to his former team Seattle with the Broncos.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your best on the first NFL Sunday slate of the season (and Monday Night Football too!).
Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!
Pickswise NFL Preview 2022
There’s still time to read the Pickswise NFL Preview, which includes full previews of all 32 teams, all our experts’ futures picks for the year and much more. You can find our FREE NFL preview here, presented by Superbook Sports.
You can also check out our:
NFL Week 1 picks
- NFL picks against the spread and total for EVERY Week 1 game
- NFL best bets
- NFL parlays
NFL Week 1 expert betting picks and predictions
- Jared Smith’s Week 1 best bets
- NFL Week 1 mega parlay (+1126 odds!)
- The Dog House: NFL best underdog bets
- NFL teaser picks
- Our NFL experts’ best bets
- Week 1 survivor pool picks
- Millionaire maker 14-team parlay
- Sunday Night Football same game parlay
- ClevTA’s Monday Night Football best bets
NFL Week 1 prop bets
- Week 1 anytime touchdown scorer picks
- Sunday 1pm game player props
- Sunday 4.25pm game player props
- Sunday Night Football props
- Sunday Night Football touchdown scorer picks
- Monday Night Football props
- ThriveFantasy NFL player props
NFL Week 1 big-game predictions
- Browns vs Panthers predictions
- Patriots vs Dolphins predictions
- Steelers vs Bengals predictions
- Packers vs Vikings predictions
- Chiefs vs Cardinals predictions
- Raiders vs Chargers predictions
- Buccaneers vs Cowboys predictions
- Broncos vs Seahawks predictions
Watch Pickswise Playbook!
Our weekly NFL show featuring guest Todd Fuhrman will get you in the know for every angle of the Week 1 slate.
Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.
