NFL betting guide: Expert 2022 Week 1 NFL picks, predictions, odds & best bets

Baker Mayfield of the Carolina Panthers
Photo of Phil Agius

Phil Agius

NFL

Show Bio

I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email contact@pickswise.com.
Read more about Phil Agius

Welcome to the Pickswise NFL Week 1 betting guide. The nation’s favorite sport is back in full force on Sunday with 28 teams playing for the first time this season — and there are some great revenge games on a sizzling slate with the Browns facing new Panthers QB Baker Mayfield and Russell Wilson returning to his former team Seattle with the Broncos.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your best on the first NFL Sunday slate of the season (and Monday Night Football too!).

Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!

Pickswise NFL Preview 2022

There’s still time to read the Pickswise NFL Preview, which includes full previews of all 32 teams, all our experts’ futures picks for the year and much more. You can find our FREE NFL preview here, presented by Superbook Sports.

You can also check out our:

NFL Week 1 picks

NFL Week 1 expert betting picks and predictions

NFL Week 1 prop bets

NFL Week 1 big-game predictions

Watch Pickswise Playbook!

Our weekly NFL show featuring guest Todd Fuhrman will get you in the know for every angle of the Week 1 slate.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

Pickswise
*
By signing up you agree to our terms and privacy policy