At 6-4, the 49ers are tied with the Seahawks at the top of the NFC West standings. Their offense has become one of the best in the NFC, and if they want to overtake the Seahawks, every win is crucial now. They face a Saints team that is struggling to find an identity but is looking to play spoiler on Sunday. Our NFL expert gives their picks, predictions and best bets for this big game.
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NFL New Orleans Saints vs San Francisco 49ers expert predictions
Since acquiring Christian McCaffrey, the 49ers are 3-1 and have looked incredibly impressive. Their only loss in that span came to the Chiefs, while the Saints have been struggling to put their offense together. New Orleans has been unpredictable in the last few weeks as they were competitive with the Ravens, shutout the Raiders, and then lost by 10 to the Steelers. San Francisco has been much more reliable, and that should shine through on Sunday.
New Orleans Saints vs San Francisco 49ers spread, odds & betting lines
Odds courtesy of DraftKings Sportsbook at time of publishing.
Spread: Saints +9, 49ers -9
Total Points Over/Under: 43.5 points
Money Line Odds: Falcons +340, Commanders -425
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Check out more of our NFL predictions for Week 12:
- Bears vs Jets predictions
- Bengals vs Titans predictions
- Falcons vs Commanders predictions
- Ravens vs Jaguars predictions
- Packers vs Eagles predictions
New Orleans Saints vs San Francisco 49ers expert picks
We’ve got 2 standout NFL picks for the clash between the Saints and 49ers.
Saints vs 49ers point spread pick: 49ers -9 (-110)
The San Francisco 49ers are picking up steam, and they’re starting to be talked about as a Super Bowl contender. They’ve won 3 in a row, most recently demolishing the Cardinals 38-10 on Monday Night Football. The defense is getting healthier, and the trade for Christian McCaffrey has given them arguably the best group of offensive weapons in the league. On the flip side, the Saints are still without a lot of their top options on offense. Andy Dalton has done a decent enough job given the circumstances, but he’s getting thrown to the wolves on the road against one of the best defenses in the NFL. New Orleans managed to get a much-needed win last week, but I’m not giving it much credit for beating a Rams team that was playing Bryce Perkins at quarterback for much of the day.
Right before that, the Saints had lost back-to-back ugly games to the Steelers and Ravens. Given that each of those defeats came by double digits, I don’t have many qualms about laying this many points with the 49ers. San Francisco clearly has the offensive upside to cover a number this large, averaging more than 30 points per contest during this current winning streak. New Orleans has played 3 road games since Week 1 and those were against the Panthers, Cardinals and Steelers. The Saints lost all 3 of those games, with each defeat coming by at least 8 points.
Be sure to check out our full Saints vs 49ers predictions
Saints vs 49ers Over/Under totals pick: Under 43.5 (-110)
I don’t see the Saints scoring much at all, so I’m going with the under. The 49ers were still managing to play pretty well on defense even with an unbelievable amount of injuries, and now that they’re a bit healthier they’re dominating. Just this past week they held the Cardinals to 2.8 yards per rush attempt while completely shutting down QB Colt McCoy, who had looked pretty good against the Rams the week before. The week before that they held Justin Herbert below 200 yards, and right before that they gave up only 14 points to the Rams.
New Orleans is still without Michael Thomas and Jarvis Landry is still hampered by an ankle issue, so other than rookie Chris Olave there isn’t really anyone in their receiving corps who scares you. The Saints have been held to 13 or fewer points in 2 of their past 3 games, and Alvin Kamara hasn’t done anything notable in weeks.
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