Monday Night Football will be in San Francisco this week as the Rams head to the Bay to take on the 49ers. In an exciting battle with two solid defenses and some high-powered weapons on offense, who will walk away victorious? It’s Monday Night Football and our NFL expert has picks and predictions for Rams vs 49ers, so let’s break it all down.
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NFL Week 4 Los Angeles Rams vs San Francisco 49ers prediction
Monday Night Football will feature an NFC West matchup as the Los Angeles Rams and the San Francisco 49ers meet for the first time this season. The 49ers have a new look with Jimmy Garoppolo at quarterback instead of Trey Lance, but can the veteran lead the Niners past the explosive Rams offense? We have a side and total pick for you, so let’s get right into it.
Los Angeles Rams vs San Francisco 49ers spread, odds & betting lines
Point spread: Rams +2; 49ers -2
Total points over/under: 42.5 points
Money line odds: Rams +105, 49ers -105
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Be sure to also check out all of our other NFL Week 4 predictions articles below.
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Los Angeles Rams vs San Francisco 49ers expert picks
We’ve got some great NFL picks for this week’s game between the Los Angeles Rams and San Francisco 49ers, including a spread and total selection.
Against the spread pick: 49ers -2 (-110) over Rams
San Francisco has covered in each of the last 5 meetings with the Rams since 2020, including the playoffs. In the same exact spot last year on a Monday Night, the Niners blew out the Rams 31-10 as 4-point underdogs at home. They realistically should have beaten the Rams in the NFC title game and were a dropped interception away from going to the Super Bowl. Of Matthew Stafford’s 21 games last year, his EPA performances against this San Francisco defense produced outcomes that ranked 9th, 13th and 20th out of those games. Only 1 game, Week 18 at home, was an above average performance last year.
The Niners offense, mainly Jimmy G, struggled against a really good Broncos defense last Sunday night but they should find more success at home and against an overrated Rams defense. No matter who the Rams end up throwing out there on Monday, the Niners and Kyle Shanahan should find major holes.
Be sure to check out our full Rams vs 49ers predictions
Over/Under totals pick: Under 42.5 points (-110)
Both of these offenses have had serious issues moving the football and capitalizing in the red zone in 2022. The 49ers offense was a disaster against the Broncos, managing to score only 10 points while tallying less than 300 yards of total offens. In that same vein, the Rams passing attack has been limited over the first 3 weeks and the running game has been even worse.
Los Angeles has failed to record 100 yards in each of its first 3 games, and that shouldn’t change against a stout 49ers front seven. The under is 4-1 in the Rams’ last 5 divisional matchups, while the 49ers are 5-0 to the under in their last 5 games following a loss. Look for both of those trends to continue in what should be a close, low-scoring contest.
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