Best San Francisco 49ers vs Seattle Seahawks Touchdown Player Prop Predictions: George Kittle makes it 4 in a row

San Francisco 49ers tight end George Kittle (85) celebrates after scoring a touchdown against the Seattle Seahawks in the fourth quarter at Levi's Stadium.
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After a great duel last week on Thursday Night Football that took overtime to settle the Buccaneers vs Falcons, let’s hope this NFC West battle is half as entertaining. Here are my 49ers vs Seahawks touchdown scorer best bets for TNF. You can also find out our NFL picks on the side and total for EVERY game in Week 6 and throughout the entire 2024 season.

Read our full San Francisco 49ers vs Seattle Seahawks predictions

49ers vs Seahawks anytime touchdown scorer pick: George Kittle (+175)

Odds available at BetMGM Sportsbook at time of publishing.

Brock Purdy peppered George Kittle with red-zone targets last week against the Cardinals. His 4 targets in the red zone were tied with Garrett Wilson and Zach Ertz for the most in Week 5. Now we turn to Week 6, where Kittle and the 49ers, off a short week, head to Seattle as 3.5-point favorites after the Seahawks lost to the Giants at home in Week 5.

Kittle has had great success against the Seahawks over the last few years. That includes 5 touchdowns in his previous 4 games against the Seahawks. But the Seahawks are under a new regime with a different defense, so we won’t put too much stock into that. On the other hand, the Seahawks rank just outside the top 10 in targets allowed to the tight end position. We’ll ride with Kittle at +175, where DraftKings is down to +140.

Add some sizzle to your Thursday with our 49ers vs Seahawks Same Game Parlay for TNF at +728 odds

49ers vs Seahawks anytime touchdown scorer pick: DK Metcalf (+160)

Odds available at Bet365 at time of publishing.

Much like Kittle, DK Metcalf enjoys this divisional battle against the 49ers. He has had 3 touchdowns over the last 2 seasons, all with cornerback Charvarius Ward active. Metcalf has the tools of a star wide receiver. He ranks in the top 10 in air yards this season, and his 11.7 aDOT leads all Seahawks receivers. As 3.5-point home underdogs and a Geno Smith passing attempts line at 36.5, I’d expect much of that work to go to Metcalf — especially in the red zone.

Get Prop Holliday’s best 49ers vs Seahawks player prop bet for TNF

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