NFL Picks

Get free expert NFL picks for every game of the 2024-25 season, helping you find key betting trends and much more in our expert NFL picks this week.

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Experts
Confidence Rating
Detroit Lions
Detroit Lions
DET
Sun Nov 24
FOX
IND
Indianapolis Colts
Indianapolis Colts
Point Spread PickBest Bet
DET Lions -6.5(-120)

The Detroit Lions will be looking to solidify their new status as Super Bowl favorites when they visit the Indianapolis Colts on Sunday afternoon. That’s right; the Detroit Lions are favored to win the Super Bowl. They assumed the top spot for the first time this season — and first time in franchise history — following this past week’s 52-6 humiliation of the Jacksonville Jaguars that coincided with the Kansas City Chiefs’ first loss. And it’s hard to argue with the odds. Detroit is an absolute wagon from an offensive standpoint. Jared Goff bounced back from his interception barrage in Week 10 by torching Jacksonville for 412 yards and 4 touchdowns on 25-of-29 passing. Amon-Ra St. Brown (2), David Montgomery (2) and Jahmyr Gibbs (1) scored at least 1 touchdown in the same game for the 8th time in their careers — already a record for 3 teammates in the history of the NFL.

Indianapolis +3.5 against the New York Jets was a 3-star best bet winner for me in Week 11, but I’m prepared to fade the Colts this time. After all, facing the Lions is the most opposite extreme you can possibly get compared to facing the Jets. Indy squandered all of a 13-0 lead over the Jets before recovering late, so that really doesn’t inspire much confidence. Jonathan Taylor averaging just 2.4 yards per carry in that game also isn’t encouraging. What’s even more worrying is that the Colts rank 26th in the league against the pass and 25th in opponents’ yards per pass attempt. How do you think they are going to stop Goff, St. Brown and the rest of the gang? I would be more than happy to play this at -7.5, which you can get at plus money (+100) at time of publishing. However, at less than a touchdown (and PAT) it evokes max confidence. The Lions should continue to roll.

Lions vs Colts prediction: Lions -6.5 (-120) available at time of publishing. Playable to -7.5 (+100).

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Game Totals Pick
Over 50.5(-110)

This is the highest total of the week, although there are 2 games just a half-point lower at time of publishing. Despite the lofty number, I have no reservations about backing the over when the Lions are involved. Their 336 points scored this season are the most in the NFL, and only the Baltimore Ravens and Buffalo Bills are even in the same ballpark. Goff and company have racked up 52 points in 2 of their last 4 outings and they have scored at least 42 points on 2 other occasions. Gibbs and Montgomery are arguably the best running-back duo in the league, more than worthy of having a nickname bestowed upon them (Sonic and Knuckles). Detroit can score on anyone, but the offense is especially scary in this situation against an opposing defense that stinks against the pass. Indianapolis isn’t any good against the run, either, ranking 28th in that department.

The only good news for the Colts is that Anthony Richardson is back under center and he once again flashed his potential with 3 total TDs against the Jets (2 rushing, 1 passing). Detroit should do most of the work, but Indy can also contribute a decent amount toward the over.

Lions vs Colts prediction: Over 50.5 (-110) available at time of publishing. Playable at that number.

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Ricky Dimon
San Francisco 49ers
San Francisco 49ers
SF
Sun Dec 1
BUF
Buffalo Bills
Buffalo Bills
Money Line Pick
BUF Bills Win(+110)

This is a line that I could see being flipped by the time we get to late November, so for our 49ers vs Bills prediction, why not take a shot with one of the best home teams in football? Prior to this Sunday Night Football matchup in Week 13, the 49ers will have played a 5-game stretch consisting of the Chiefs, Cowboys, Buccaneers, Seahawks and Packers. Not only were 4 of those 5 teams in the playoffs last season, but the 49ers will have just played the Packers at Lambeau Field in a massive revenge spot for Green Bay the week prior to this contest. On the other hand, the Bills will be coming off a much-needed bye week after completing a pivotal 8-game stretch of their schedule.

There’s an argument to be made that the 49ers are overvalued in the market heading into this season, so this number could easily be Bills -2.5 by the time we hit kickoff. Yes, Buffalo can be frustrating in close games against lesser competition, but Josh Allen and company have typically risen to the occasion in these home spots (see: last season vs Miami & Dallas), so it’s hard not to back the Bills as home underdogs in this one for our 49ers vs Bills best bet.

49ers vs Bills prediction: Bills ML (+110) available at time of publishing.

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Caleb Wilfinger

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Why Pickswise Is The Home Of The Best Free Expert NFL Picks For The 2024 Season

There are just 18 weeks in the NFL regular season with a maximum of 16 games per week, but NFL Betting is easily the most popular in North American amongst bettors. Our expert handicappers have decades of industry experience where they have honed in on their craft to provide the best insight, analysis, and value picks here at Pickswise. All of our NFL picks are completely free, including our picks straight up, and against the spread.

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There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, over/under, NFL Parlays, NFL Prop Bets, daily fantasy sports, or even scoreboard squares, there is a bet type for every kind of football fan. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick. Here at Pickswise, we’ll have something for everyone with our team of handicappers leaving no stone unturned ahead of every game in the 2024 NFL season. 

Free NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

A fun stat worth noting is that the team that covers the spread wins the game outright around 80% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with total wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game alongside expert NFL picks.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams are only looking to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks.

2024-25 NFL Schedule 

This will be the 105th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 5, hosted by the defending Super Bowl Champions Kansas City Chiefs, who take on the Baltimore Ravens. The regular season will come to a conclusion on January 5, 2025 with the NFL Playoffs scheduled to begin the following weekend on the 11th & 12th of January 2025. Super Bowl LIX is scheduled for February 9, 2025, at Caesars Superdome in New Orleans, Louisiana, the home of the New Orleans Saints.

NFL Picks This Week

You can find our latest NFL picks by week, all season long below:

Weekly NFL Picks
NFL Week 1 PicksNFL Week 2 Picks
NFL Week 3 PicksNFL Week 4 Picks
NFL Week 5 PicksNFL Week 6 Picks
NFL Week 7 PicksNFL Week 8 Picks
NFL Week 9 PicksNFL Week 10 Picks
NFL Week 11 PicksNFL Week 12 Picks
NFL Week 13 PicksNFL Week 14 Picks
NFL Week 15 PicksNFL Week 16 Picks
NFL Week 17 PicksNFL Week 18 Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Football Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting and our confidence rating in those picks. You can also head to our NFL Football Best Bets page for the top plays on the week. Or looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of coverage and expertise from the Pickswise handicapping team.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every single day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season. 

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

 

 

Pickswise is the best website to get free expert NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. 

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week. Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods.

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