St. Louis Cardinals vs Boston Red Sox Prediction, Odds and Picks for Today, 04/04/25

The St. Louis Cardinals and Boston Red Sox are set to start their 3-game series on Friday afternoon, and I am favoring the over on the posted total to get the series going. St. Louis has had a hot start offensively this season, averaging the second-most runs per game in MLB at 7.00 through their first 6 games. The team has a 4-2 record so far thanks to a strong start at the plate, and I expect such success to continue against Walker Buehler and company on Friday. Cardinal hitters have 28 hits in just 18.2 combined innings against the 4 opposing right-handed starters they have seen so far, and Buehler had a shaky debut with Boston last week. The former Cy Young Award winner allowed 7 hits, including a home run, and 4 earned runs on the way to a loss against the Texas Rangers. It will be interesting to see how he pitches at Fenway Park this season, and on Friday we get our first chance to see it play out.

Erick Fedde was far sharper in his 2025 debut, tossing 6.0 innings with just 1 earned run and 2 baserunners allowed. He was efficient with just 73 pitches across 20 total batters faced, earning 9 ground-ball outs to just 2 strikeouts. Boston has had its fair share of strikeout problems so far this season so we should expect to see a bit more swing-and-miss from Fedde this time around. Still, Boston is too talented offensively to continue producing at a bottom-tier level and returning home to play in front of its fans for the first time this season could be the juice it is looking for. I like the over 8.5 between these 2 teams in their matchup on Friday, as we could see double-digit runs scored.

Cardinals vs Red Sox prediction: Over 8.5 (-122) available at time of publishing. Playable to 9.

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