San Diego Padres vs Detroit Tigers Prediction, Odds and Picks for Today, 04/22/25
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Padres vs Tigers Pickswise Expert Predictions
Interleague play continues on Tuesday night as the San Diego Padres look for redemption against the Detroit Tigers. Detroit came out swinging in Monday’s matchup, putting up 6 runs in the first 3 innings, and they’ll look to keep things rolling as they send Jack Flaherty to the mound. Both teams sit atop their division and for good reason as they are loaded with talent. Tonight’s matchup should be a fun one to watch as I expect it to be a pitchers’ duel. The Padres will try to bounce back after dropping 4 of their last 6 games, while the Tigers look to ride their momentum, winning 4 of their last 6.
Taking the mound for the Padres will be Nick Pivetta, who is 3-1 with a 1.57 ERA this season. Pivetta looked strong in his last start against the Cubs, giving up just 1 earned run on 4 hits and striking out 6 in 6 innings pitched. For the Tigers, Jack Flaherty is set to take the mound, who is 1-1 with a 2.53 ERA this season. Flaherty struggled in his last start against the Brewers, giving up 3 earned runs in 4.2 innings pitched, but in 21.1 innings pitched this season, he has struck out 25 and has a WHIP of 1.08.
Looking at the recent hitting stats, the Padres have been smacking the ball well of late, batting .266 with 15 home runs and averaging 4.2 runs per game in their last 13 games. For the Tigers, they’re hitting .236 with 11 home runs and are averaging 4.4 runs per game in their last 14. In terms of pitching, I think the Padres have the advantage with Pivetta on the mound, as he’s been able to go longer into the ball games than Flaherty so far this season. However, if either team has to go to their bullpen, it shouldn’t worry either of them. The Padres have the best bullpen ERA this season sitting at 1.46 and the Tigers are at 2.86. Despite the Padres’ recent struggles, I think they’re in a good position to bounce back in this matchup, making San Diego on the money line my best bet of the day.
Padres vs Tigers prediction: Padres ML (-105) available at time of publishing. Playable at that number.
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Jason Fragomeni
The Padres have won 5 of 7 games following a defeat.
The Tigers are showing a profit of 4.24 units on the run line in their last 5 games at Comerica Park.
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