San Diego Padres vs Detroit Tigers Prediction, Odds and Picks for Monday, 04/21/25

In this game, we will see the San Diego Padres travel from Houston to take on the Detroit Tigers. The Padres are coming off a losing series against the Houston Astros where they saw Luis Arraez get injured yesterday. On the other side, the Tigers are coming off winning a series against the Kansas City Royals. This should be a high-quality matchup between 2 teams that are leading their divisions.

On the mound, we will see Randy Vasquez for the Padres and Keider Montero for the Tigers. Vasquez has pitched 20.2 innings giving up 14 hits and 4 earned runs. This is a fantastic start for him. The Padres have lost 2 out of his 4 starts because the bats were not working those days. Montero has only pitched once this year where he pitched 5 innings giving up 8 hits and 5 runs against the Milwaukee Brewers. This does not give us a lot of information, but he did struggle against the Padres last season giving up 7 hits and 5 runs in 4.1 innings. To top off the pitching for this one, we have 2 of the top 5 bullpens in the league going against each other in this series.

All in all, the edge in this one is found on the mound. Vasquez has shown some toughness this year in his starts, and it is about time the Padres bats start helping him out. Along with this, we have Montero coming off a struggling first game. He is now going up against the Padres who hold the top batting average in the MLB. We are getting the Padres as an underdog because of the travel, but the data points to the fact that they should probably be favored in this one.

Padres vs. Tigers Prediction: Padres ML (+110) available at the time of publishing. Playable at that number.

Now you can bet any of our Padres vs Tigers predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you earn a welcome bonus worth up to $250 if your first $5 bet wins! 🔗 to join FanDuel right now and learn more.