San Diego Padres vs Chicago Cubs Prediction, Odds and Picks for Today, 04/05/25

The San Diego Padres are looking to get back into the win column against the Chicago Cubs when they meet at Wrigley Field on Saturday afternoon. The Padres dropped Friday’s contest by a score of 3-1, but they have a solid shot at bouncing back with a win on Saturday. Nick Pivetta will take the mound for San Diego in this one, and he looked nearly untouchable in his first outing of the season, allowing just a single hit over 7 innings against the Cardinals. On the other side, Chicago starting pitcher Matthew Boyd didn’t allow any runs in his first start of the season against the Diamondbacks, but he gave up 4 hits and 3 walks. Things weren’t exactly easy for Boyd, and he may have a tough time going up against a San Diego lineup that is 8th in the league with a .772 OPS against lefties so far this season.

The San Diego bullpen has been lights-out so far this season, as they boast an MLB-best 0.60 ERA and .127 BAA, along with an NL-best 0.77 WHIP. The Cubs have been scoring a ton of runs so far this season, but after scoring just 3 runs in Friday’s win, that same production might not be enough in this one. The Padres rattled off 7 straight wins to start the 2025 campaign before Friday’s loss, and they rank 4th in MLB with a .284 batting average on the season. Look for Mike Shildt’s squad to find the win column in this one.

Padres vs Cubs prediction: Padres ML (+105) available at time of publishing. Playable to at that number.

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