Philadelphia Phillies vs Chicago Cubs Prediction, Odds and Picks for Saturday, 04/26/25

The Cubs have been one of the hottest teams in baseball this April, going 14-6 while averaging 6.2 runs per game. The Phillies, on the other hand, are 10-12 in the month of April and are averaging 3.9 runs per game — something you wouldn’t expect from a team with the kind of talent they have. Today the Cubs will look to keep their red-hot streak alive, but they’ll have their hands full against a Phillies team eager to turn things around.

Taking the mound for the Phillies will be Jesus Luzardo, who is 2-0 with a 2.08 ERA in 5 starts this season. Luzardo is exactly what the Phillies need right now, a left-handed pitcher than can eat up innings and put them in a position to win this game as they get ready to face a Cubs pitcher who has struggled early on. For the Cubs, Ben Brown will get the nod; he is 2-1 with a 4.57 ERA. Brown struggled struggled in his first few starts on the year, but in his last two starts he’s given up just one earned run in 10 innings pitched. One thing to note is that Brown doesn’t go deep into the games, which can be troublesome for the Cubs when their bullpen comes into play. Chicago’s bullpen has an ERA of 4.96 this season, which could open the door for the Phillies late in this game. The Cubs are first in the league in batting average (.296) against lefties this year, so does this spell trouble for Luzardo and the Phillies? Looking into this matchup, the Phillies still have the advantage with Luzardo and Brown will be tested in this lineup. Despite the way the Cubs have been swinging their bats as of late, I think Philadelphia will have plenty of opportunities to score runs in today’s matchup and steal a win on the road. 

Phillies vs Cubs prediction: Philadelphia ML (-115) available at time of publishing. Playable at that number.

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