New York Yankees vs Cleveland Guardians Prediction, Odds and Picks for Monday, 04/21/25

The New York Yankees and Cleveland Guardians are set to meet for the first time since their matchup in last season’s American League Championship Series. The Yankees took that series in 5 games, and they return to Cleveland with the best record in the American League at 14-8. They have been victorious in 7 of their last 10 games, and Aaron Boone’s squad should be able to keep the momentum going in this one.

The starting pitching matchup in this game features Clarke Schmidt for New York and Gavin Williams for Cleveland. Williams is still finding his footing as a big leaguer, as he owns a 4.10 ERA in his career, and a 4.58 ERA through 4 starts this season. His xERA of 5.25 this season is concerning, and things won’t get any easier as he goes up against Aaron Judge and company tonight. Schmidt wasn’t particularly effective in his first outing against Kansas City, but tonight he gets to face a Cleveland lineup that owns a lowly .648 OPS at home this season, which ranks 26th in the league. The Guardians might not have enough pop in their lineup to keep up with the Yankees in this one. Back New York on the road.

Yankees vs Guardians prediction: Yankees ML (-115) available at time of publishing. Playable to -120.

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