Minnesota Twins vs Cleveland Guardians Prediction, Odds and Picks for Today, 04/28/25

The Minnesota Twins head to Progressive Field to kick off a 4-game series Monday against the division rival Cleveland Guardians. The Twins are looking to stay hot after sweeping a weekend series from the beleaguered Los Angeles Angels to get back to within 4 games of .500. Minnesota has won 5 of the past 6 games, too, while winning back-to-back series for the first time this season. While that’s all well and good, the Twins are just 3-10 on the road, with 2 of those victories against the lowly Chicago White Sox. The Twins hand the ball to RHP Bailey Ober, who has a 2-1 record in 5 starts, but he also has a dismal 5.04 ERA across 25 IP.

The Guardians turn to RHP Gavin Williams for the opener, and he is brimming with confidence after turning in a win and quality start last time out against the high-octane New York Yankees offense last Monday at Progressive Field. Williams was 1-1 with a 2.45 ERA across 2 starts against the Twins in 2024, with Minnesota hitting just .209 against him. We’ll back the Guardians to splash cold water on the Twins, as Minnesota is a completely different team on the road. It is just 1-5 in the past 6 tries against the Guards, too, while also going 1-5 in the past 6 games at Progressive Field.

Twins vs Guardians prediction: Guardians ML (-125) available at time of publishing. Playable to -140.

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