Milwaukee Brewers vs San Francisco Giants Prediction, Odds and Picks for Monday, 04/21/25

The Milwaukee Brewers and San Francisco Giants square off in an intriguing NL clash, each team looking to keep pace in competitive divisions. Milwaukee enters at 12-10, sitting second in a wide-open NL Central. After early struggles on the mound, the Brewers’ staff has locked in, allowing no more than three runs in each of their last five contests. They’ll hand the ball to Quinn Priester, a recent addition from Boston who has impressed in two starts—going five innings in each and sporting a 0.90 ERA. But Priester faces a stiffer test today. While his early success is promising, a bit of regression feels inevitable, especially against a Giants lineup eager to bounce back after dropping two of three to the Angels. San Francisco, at 14-8, sits third in a loaded NL West and needs every win to keep pace with the Padres and Dodgers.

Robbie Ray gets the nod for the Giants, and while his 4.19 ERA doesn’t jump off the page, his 3-0 record and the team’s 7.5 runs-per-game average in his starts show how well they’ve supported him. The Giants have scored 4+ runs 13 out of 18 games in April, and with Milwaukee’s bullpen still sporting a 5.14 ERA, San Francisco should have opportunities late even if Priester holds up early.

Brewers vs Giants Prediction: Giants Team Total over 3.5 (-145) available at time of publishing. Playable to 4

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