Cleveland Guardians vs San Diego Padres Prediction, Odds and Picks for Wednesday, 04/02/25

In this matchup, we will see the Cleveland Guardians take on the San Diego Padres for the third and final game of the series. Through the first 2 games of the series, the Guardians have been struggling. They have scored a total of 2 runs and amassed a total of 10 hits. On the opposite end of the spectrum, the Padres are riding some momentum as they are going for their sixth straight home win and the second sweep of the season. Through the first two games, they have scored 14 runs with a total of 22 hits. Clearly the bats are working for the Padres at the moment.

On the mound for this game will be Ben Lively for the Guardians facing off against Dylan Cease for the Padres. So far, both pitchers have taken the mound for one game and both teams came away with the win in the previous series. While both teams won the game in those outings, neither pitcher was particularly impressive. Lively pitched against the Kansas City Royals and gave up 4 hits and 3 runs through 5 innings. Cease took the mound against the Atlanta Braves and gave up 4 hits and 3 runs through 4.1 innings. As we can see, in their debut games of 2025 they were both lackluster.

While we have a slight lean towards the Padres just following the momentum of their hitting. There is one statistical area where they have gained a clear edge- overall pitching when we add in the bullpen. Prior to the most recent game, the Padres have an overall ERA of 1.8 and have given up 26 hits and 9 earned runs. The Guardians on the other hand, have an overall ERA of 3.86 and have given up 34 hits and 15 earned runs having played one less game. Given these pitching statistics, the bats of the Padres, and the overall momentum that the Padres bring into this game, I think it is time to break out the brooms.

Guardians vs. Padres Prediction: Padres -1.5 (+125) available at the time of publishing. Playable at that number.

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