Baltimore Orioles vs Arizona Diamondbacks Prediction, Odds and Picks for Monday, 04/07/25

Monday’s matchup between the Arizona Diamondbacks and the Baltimore Orioles is setting up to be an interesting game to kick start their series. Arizona is fresh off of a 6-game road trip and will be happy to return home after losing 3 of those final 4 contests. They will turn to Zac Gallen in this spot, as the right-hander makes his third start of the season. He was shaky in his season debut against the Cubs, lasting just 4 innings while allowing 8 baserunners and 4 runs to cross the plate. Gallen rebounded very nicely in his next start, holding a potent Yankees lineup scoreless across 6.2 innings of work while racking up 13 strikeouts to zero walks issued. His command was on point and he hopes to carry that momentum over to his matchup with the Orioles.

Zach Eflin will draw his third start of the season for Baltimore and while he has pitched decently well so far, this is not my favorite matchup for him. He is an innings eater that attacks the zone regardless of matchup in hopes to record 6 efficient innings, but the Arizona lineup has been rolling against right-handed pitching and will likely provide Gallen with an early lead. This game should be great entertainment with star power on both sides and teams that don’t often get to play, but I lean toward Arizona winning game 1 of this series.

Diamondbacks vs Orioles prediction: Arizona ML (-130) available at time of publishing. Playable at that price.

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