Arizona Diamondbacks vs Washington Nationals Prediction, Odds and Picks for Today, 04/04/25

The Friday night slate takes us to our nation’s capital for an Arizona Diamondbacks vs Washington Nationals prediction. The Nats return home after dropping 3 in Canada this week, and they are off to a cold 1-5 start. The Diamondbacks are playing far better baseball, splitting with the Cubs and taking 2 of 3 from the Yankees. The Snakes look like a very strong team in a loaded NL West, while the Nats have a young and exciting core of players who are trying to figure things out at the Big League level. I expect to back the Nats often this season, but maybe not at this particular moment. My Diamondbacks vs Nationals pick is Arizona on the money line.

Brandon Pfaadt and Jake Irvin will be the starters. Irvin is an effective starter, even if largely unknown. Pfaadt is an exciting young arm, but too many of his starts have the same pattern: 5 innings of work in which 4 of those innings are dominant and the other is a mess. Pfaadt needs to avoid that messy inning on Friday. This one for me comes down to context. The Nats have won only 1 game, and they have lost the other 5 by at least 2 runs each time. Their lineup is still learning, and they are undependable. The D-Backs, on the other hand, boast one of the better lineups in the NL. I think the D-Backs will just out-slug the Nats in this case. Give me Arizona to win.

Diamondbacks vs Nationals prediction: Arizona ML (-140) available at time of publishing. Playable at that number.

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