MLB Best Bets

Welcome to the home of our MLB best bets. Our expert handicappers analyze all of the latest team news, statistics, form, and trends to bring to you our MLB best bets. For the remainder of our MLB picks, including a pick for each game of the MLB season, head over to our MLB Picks and MLB Predictions pages.

Our MLB best bets will be released at the latest at 11 am EST once all lines have become available with sportsbooks.

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Money Line PickBest Bet

NL Win(-110)2025 MLB All-Star Game

Reasoning

Major League Baseball will play its 96th All-Star Game on Tuesday, and they will do it in Atlanta’s Truist Park. If you are interested in century-long trends, this game is pretty even, with the AL leading the series 48-44 (there isn’t always a winner). More recently, of course, the AL has dominated the Senior Circuit, winning 22 of the previous 27. When the AL took last year’s game, 5-3, it broke up a modest 1-game winning streak for the National League. Of course, I’m not sure any of that really matters when it comes to an exhibition game that (thankfully) has nothing at stake and in which the roster is different every year. But I’m sure plenty of people (myself included) will want action on this game because it is the only show in town on Tuesday (with apologies to Caitlin Clark and Sophie Cunningham). So, what shall we do? Me, I am going with the NL.

When all the dust settles and we figure out who is playing or opting out, who is available to pitch and who isn’t, and all of those very key but very difficult things to ascertain, I think I like the NL roster better. We all know about Tarik Skubal vs Paul Skenes in the first inning, which is cool. But the rest of the pitching? On the AL side, we will NOT see Garrett Crochet, Max Fried, Yusei Kikuchi, Jacob deGrom or Hunter Brown. On the NL side, we will NOT see Zack Wheeler, Yoshinobu Yamamoto, Robbie Ray or Freddy Peralta. Most of those guys pitched over the weekend and aren’t available. I almost prefer to try to guess who will give up runs instead. Clayton Kershaw? Kris Bubic? One of the 3 (yes, three) Padres relievers on the roster?

And the lineups? Look, everyone here is good, that’s why it is an All-Star Game. But when we get into the late innings and the non-starters are in the game, I definitely like the NL depth better. This game probably finishes with Fernando Tatis Jr., James Wood and Corbin Carroll in the outfield, and Kyle Schwarber and Elly de la Cruz in the lineup too. I’ll take my chances with those guys. The AL roster seems thin to me. It would be mean to say it is Cal Raleigh, Aaron Judge and whoever else would agree to play, but it is definitely not a collection of the truly best players in the AL. We all know this game will come down to a random solo homer somewhere in the middle innings, and that is always just a shot in the dark for our betting card, but I am going with the National League to deliver in Atlanta.

2025 MLB All-Star Game prediction: National League ML (-110) available at time of publishing. Playable at that number.

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Chad Hartsock

MLB Best Bets

49.5%

Win %

54Wins

55Losses

0Pushes

Percentage only includes Wins and Losses

What Are Our MLB Best Bets

At Pickswise our expert handicappers spend hours analyzing each match of the MLB season, delving into the latest MLB statistics, team news, travel, schedule, weather, trends to name just a few angles we cover and consider.

With a typical MLB regular season containing a total of 2,430 games, researching this many games in the required depth is an exhaustive task. Our experts take care of all of that, so you don’t have to.

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Baseball Betting – Best Baseball Bets Today

Baseball betting can be tricky with so many games played each day and across the season – 2,340 in just the regular season alone! There are also many different ways that you can wager on baseball betting, from traditional markets like the Money Line, Run Line, and Runs Totals, to MLB Prop Bets such as player runs, hits, and strikeouts, or Team Props such as team runs or innings betting. Our baseball best bets page is the best place to start when looking at your baseball betting today. Here our expert handicappers post their best baseball bets on today’s slate with full analysis, reasoning, and odds. Check out our MLB Predictions and MLB Picks pages for all of our other baseball betting previews and picks.

MLB Lock Of The Day – MLB Lock Picks Today

Looking for MLB Lock Picks today? Well, you’re in the right place. At Pickswise, our MLB Lock picks will be right here on our MLB Best Bets page every day of the regular season and into the MLB playoffs. With 2,430 regular-season games played alone in an MLB season, and numerous games played on any given day, it’s not wise to bet on them all. What you’ll find here is our MLB expert handicappers’ MLB Lock Of The Day, our most confident pick. Each MLB Lock Pick will be accompanied by a full match preview and analysis including why we have this as being a lock. You can also check out how our MLB Lock picks have fared across the season, with our 2024 MLB Best Bets Record displayed at the top of this page.

Be sure to check out our MLB Picks and MLB Predictions for all of our other MLB bets on today’s games.