Villanova Wildcats vs Seton Hall Pirates Prediction, Odds and Picks for Wednesday, 02/26/25

The Wildcats of Villanova picked up a huge 81-66 victory last time out on Friday against Marquette, and it has shown that it can be very, very dangerous at home. It was the second Quad 1 win in the past two weeks for the Wildcats, as they also upended St. John’s on Feb. 12. The problems for the Wildcats begin when they stray away from Philadelphia, as Villanova has dropped five of the past six games on the road, with the lone exception a victory over lowly DePaul on Feb. 5. In that game, Villanova was horrific offensively, but it won 59-49, leaning heavily on its defense. The Wildcats are 5-1 against the spread (ATS) in the past six games.

The Pirates of Seton Hall are looking to avenge a 79-67 loss at Villanova on Dec. 17, as the Wildcats also covered as 8-point favorites as the Over (126) cashed. Seton Hall has had a dismal season, although it did upend UConn 69-68 in overtime at “The Pru” on Feb. 15 as a 13.5-point underdog, showing it can rise up and bite an unprepared team, or one taking it lightly. Seton Hall has covered the past two games at home, while going 3-1 ATS in the past four in front of the home fans. Villanova might get the job done, but it has struggled on the road, while Seton Hall has shown some ability to at least keep it close at home lately. Back the Pirates catching more than four buckets.

Seton Hall +8.5 (-110) at time of publishing. Playable at that number.